LDN193189(DM 3189) is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
Effect of LDN-193189 on BMP signaling and function. (b) Quantitative immunoblotting of PASMCs showing differential effects of dorsomorphin or LDN-193189 on BMP4–induced (10 ng ml−1) phosphorylation of Smad1, Smad5 and Smad8 (p-Smad1/5/8), with IC50values of ~400 nM and ~5 nM, respectively.