The dimer interface of Gr6 framework is contributed by hydrophobic interaction shaped by residues positioned on b-strands F and G, element of the CDR3 loop and b -strands C and C” (Fig. 4A and 4B)
The monomer composition of Gr6 has the same fold as the canonical immunoglobulin variable domain, consisting of two b sheets with 5 and 4 strands. Gr6 shares seventy six% sequence…