Chiatry 21:519528. 23. Folstein MF, Folstein SE, McHugh PR ��Mini-mental state”. A practical strategy for grading the cognitive state of sufferers for the clinician. J Docosahexaenoyl ethanolamide web Psychiatr Res 12:189198. 24. Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, et al. Depression is linked to low plasma Abeta42 independently of cardiovascular Madrasin price illness inside the homebound elderly. Int J Geriatr Psychiatry 22:536542. 25. Lahoz C, Osgood D, Wilson PW, Schaefer EJ, Ordovas JM Frequency of phenotype-genotype discrepancies at the apolipoprotein E locus inside a large population study. Clin Chem 42:18171823. 26. Peila R, Rodriguez BL, Launer LJ Variety two diabetes, APOE gene, as well as the risk for dementia and connected pathologies: The Honolulu-Asia Aging Study. Diabetes 51:12561262. 27. van Oijen M, Hofman A, Soares HD, Koudstaal PJ, Breteler MM Plasma Abeta and Abeta plus the danger of dementia: a potential case-cohort study. Lancet Neurol 5:655660. 28. Graff-Radford NR, Crook JE, Lucas J, Boeve BF, Knopman DS, et al. Association of low plasma Abeta42/Abeta40 ratios with increased imminent threat for mild cognitive impairment and Alzheimer illness. Arch Neurol 64:354 362. 29. Selkoe DJ The ups and downs of Abeta. Nat Med 12:758759; discussion 759. 30. Zhang-Nunes SX, Maat-Schieman ML, van Duinen SG, Roos RA, Frosch MP, et al. The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol 16:3039. 31. van Dijk EJ, Prins ND, Vermeer SE, Hofman A, van Duijn CM, et al. Plasma amyloid beta, apolipoprotein E, lacunar infarcts, and white matter lesions. Ann Neurol 55:570575. 32. Gurol ME, Irizarry MC, Smith EE, Raju S, Diaz-Arrastia R, et al. Plasma betaamyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology 66:2329. 33. Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, et al. Age-dependent alterations in brain, CSF, and plasma amyloid protein inside the Tg2576 transgenic mouse model of Alzheimer’s illness. J Neurosci 21:372 381. 34. DeMattos 22948146 RB, Bales KR, Parsadanian M, O’Dell MA, Foss EM, et al. Plaque-associated disruption of CSF and plasma amyloid-beta equilibrium within a mouse model of Alzheimer’s disease. J Neurochem 81:229 236. 35. Roses AD, Strittmatter WJ, Pericak-Vance MA, Corder EH, Saunders AM, et al. Clinical application of apolipoprotein E genotyping to Alzheimer’s disease. Lancet 343:15641565. 36. Greenberg SM, Rebeck GW, Vonsattel JP, Gomez-Isla T, Hyman BT Apolipoprotein E epsilon four and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 38:254259. 37. Golpon HA, Puechner A, Welte T, Wichert PV, Feddersen CO Vasorelaxant effect of glucagon-like peptide-amide and amylin on the pulmonary circulation with the rat. Regul Pept 102:8186. 38. Tanzi RE A genetic dichotomy model for the inheritance of Alzheimer’s illness and prevalent age-related problems. J Clin Invest 104:11751179. 39. Pieber TR, Roitelman J, Lee Y, Luskey KL, Stein DT Direct plasma radioimmunoassay for rat amylin-: concentrations with acquired and genetic obesity. Am J Physiol 267:E156164. 40. Mitsukawa T, Takemura J, Nakazato M, Asai J, Kanagawa K, et al. Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load. Diabetes Res Clin Pract 15:131134. 41. Makimattila S, Fineman MS, Yki-Jarvinen H Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes. J Clin Endocrinol Metab 85:28222827. 42. Hou X, Sun L, Li Z, Mou H, Yu Z, et al. Associati.Chiatry 21:519528. 23. Folstein MF, Folstein SE, McHugh PR ��Mini-mental state”. A practical system for grading the cognitive state of individuals for the clinician. J Psychiatr Res 12:189198. 24. Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, et al. Depression is associated with low plasma Abeta42 independently of cardiovascular disease inside the homebound elderly. Int J Geriatr Psychiatry 22:536542. 25. Lahoz C, Osgood D, Wilson PW, Schaefer EJ, Ordovas JM Frequency of phenotype-genotype discrepancies in the apolipoprotein E locus inside a massive population study. Clin Chem 42:18171823. 26. Peila R, Rodriguez BL, Launer LJ Kind two diabetes, APOE gene, plus the threat for dementia and connected pathologies: The Honolulu-Asia Aging Study. Diabetes 51:12561262. 27. van Oijen M, Hofman A, Soares HD, Koudstaal PJ, Breteler MM Plasma Abeta and Abeta plus the danger of dementia: a potential case-cohort study. Lancet Neurol five:655660. 28. Graff-Radford NR, Crook JE, Lucas J, Boeve BF, Knopman DS, et al. Association of low plasma Abeta42/Abeta40 ratios with increased imminent threat for mild cognitive impairment and Alzheimer illness. Arch Neurol 64:354 362. 29. Selkoe DJ The ups and downs of Abeta. Nat Med 12:758759; discussion 759. 30. Zhang-Nunes SX, Maat-Schieman ML, van Duinen SG, Roos RA, Frosch MP, et al. The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol 16:3039. 31. van Dijk EJ, Prins ND, Vermeer SE, Hofman A, van Duijn CM, et al. Plasma amyloid beta, apolipoprotein E, lacunar infarcts, and white matter lesions. Ann Neurol 55:570575. 32. Gurol ME, Irizarry MC, Smith EE, Raju S, Diaz-Arrastia R, et al. Plasma betaamyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology 66:2329. 33. Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, et al. Age-dependent changes in brain, CSF, and plasma amyloid protein inside the Tg2576 transgenic mouse model of Alzheimer’s illness. J Neurosci 21:372 381. 34. DeMattos 22948146 RB, Bales KR, Parsadanian M, O’Dell MA, Foss EM, et al. Plaque-associated disruption of CSF and plasma amyloid-beta equilibrium within a mouse model of Alzheimer’s disease. J Neurochem 81:229 236. 35. Roses AD, Strittmatter WJ, Pericak-Vance MA, Corder EH, Saunders AM, et al. Clinical application of apolipoprotein E genotyping to Alzheimer’s illness. Lancet 343:15641565. 36. Greenberg SM, Rebeck GW, Vonsattel JP, Gomez-Isla T, Hyman BT Apolipoprotein E epsilon 4 and cerebral hemorrhage related to amyloid angiopathy. Ann Neurol 38:254259. 37. Golpon HA, Puechner A, Welte T, Wichert PV, Feddersen CO Vasorelaxant impact of glucagon-like peptide-amide and amylin around the pulmonary circulation of the rat. Regul Pept 102:8186. 38. Tanzi RE A genetic dichotomy model for the inheritance of Alzheimer’s illness and prevalent age-related disorders. J Clin Invest 104:11751179. 39. Pieber TR, Roitelman J, Lee Y, Luskey KL, Stein DT Direct plasma radioimmunoassay for rat amylin-: concentrations with acquired and genetic obesity. Am J Physiol 267:E156164. 40. Mitsukawa T, Takemura J, Nakazato M, Asai J, Kanagawa K, et al. Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load. Diabetes Res Clin Pract 15:131134. 41. Makimattila S, Fineman MS, Yki-Jarvinen H Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and kind two diabetes. J Clin Endocrinol Metab 85:28222827. 42. Hou X, Sun L, Li Z, Mou H, Yu Z, et al. Associati.