3a,7a-Dihydroxy-5b-cholestanoyl-CoA
First activated by a fatty acyl-CoA ligase activity, can then be converted to chenodeoxycholic acid by peroxisome rich fractions from rat and human liver (J Lipid Res. 1988 Aug;29(8):997-1004, PMID 3183523 ).
Structure for HMDB02159 (3a,7a-Dihydroxy-5b-cholestanoyl-CoA)
C48H80N7O19P3S
1184.171
1183.444253639
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-[({[({3-[(2-{[2-({6-[(2S,5R,7S,9R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2-methylheptanoyl}slifanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-{[({3-[(2-{[2-({6-[(2S,5R,7S,9R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2-methylheptanoyl}slifanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-4-hydroxyoxolan-3-yl]oxyphosphonic acid
2461-62-3
SBYLHTNKEWSLBA-CPRJDYHCSA-N
Not classified
Expected but not Quantified
Solid
Predicted LC-MS/MS Spectrum – 10V, Positivesplash10-000i-1900112000-0c75e0a93454d43ab753View in MoNA
Predicted LC-MS/MS Spectrum – 20V, Positivesplash10-000i-0900314000-ee39276da14ef1ec86d2View in MoNA
Predicted LC-MS/MS Spectrum – 40V, Positivesplash10-000i-1900000010-5f6513051536bb79e578View in MoNA
Predicted LC-MS/MS Spectrum – 10V, Negativesplash10-00lr-2901332400-00267947c2aa67bae2f7View in MoNA
Predicted LC-MS/MS Spectrum – 20V, Negativesplash10-003r-3900111010-35ffb32be4339618cff9View in MoNA
Predicted LC-MS/MS Spectrum – 40V, Negativesplash10-057i-6900100000-125c30cd4205b3d5be3dView in MoNA
Not Available
Not Available
Not Available
None
None
Not Available
Not Available
Not Available
Not Available
FDB022875
Not Available
389367
C04644
Not Available
44249
Not Available
HMDB02159
HMDB02159
6517
440420
Not Available
15494
Product: Diiodohydroxyquinoline
- Prydz K, Kase BF, Bjorkhem I, Pedersen JI: Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver. J Lipid Res. 1988 Aug;29(8):997-1004. [PubMed:3183523 ]
Enzymes
- General function:
- Involved in transferase activity, transferring acyl groups other than amino-acyl groups
- Specific function:
- Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
- Gene Name:
- ACAA2
- Uniprot ID:
- P42765
- Molecular weight:
- 41923.82
Reactions
- General function:
- Involved in transferase activity, transferring acyl groups other than amino-acyl groups
- Specific function:
- Not Available
- Gene Name:
- ACAA1
- Uniprot ID:
- P09110
- Molecular weight:
- 34664.46
Reactions
- General function:
- Involved in transferase activity, transferring acyl groups other than amino-acyl groups
- Specific function:
- Not Available
- Gene Name:
- HADHB
- Uniprot ID:
- P55084
- Molecular weight:
- 51293.955
Reactions
- General function:
- Involved in catalytic activity
- Specific function:
- Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
- Gene Name:
- SLC27A5
- Uniprot ID:
- Q9Y2P5
- Molecular weight:
- 75384.375
Reactions
- General function:
- Involved in acyl-CoA dehydrogenase activity
- Specific function:
- Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.
- Gene Name:
- ACAD8
- Uniprot ID:
- Q9UKU7
- Molecular weight:
- 45069.39