Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of GSK343 diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial three.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, reproduction and distribution with the operate without having additional permission supplied the original operate is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).2 water content material, volume, or frequency of stools.11 A reduce in consistency (ie, soft or liquid) and a rise within the frequency of bowel movements to 3 stools every day have normally been employed as a definition for epidemiological investigations. Determined by a community-based study point of view, diarrhea is defined as a minimum of 3 or extra loose stools within a 24-hour period.12 A diarrheal episode is thought of because the passage of 3 or far more loose or liquid stools in 24 hours before presentation for care, which is viewed as the most practicable in young children and adults.13 Having said that, prolonged and persistent diarrhea can last involving 7 and 13 days and at least 14 days, respectively.14,15 The illness is extremely sensitive to climate, showing seasonal variations in a lot of sites.16 The climate sensitivity of diarrheal illness is consistent with observations in the direct effects of climate variables around the causative agents. Temperature and relative GSK2879552 biological activity humidity possess a direct influence on the price of replication of bacterial and protozoan pathogens and on the survival of enteroviruses within the environment.17 Overall health care journal.pone.0169185 looking for is recognized to become a result of a complicated behavioral approach that is definitely influenced by many elements, such as socioeconomic and demographic and traits, perceived want, accessibility, and service availability.Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This article is distributed below the terms from the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, reproduction and distribution on the function devoid of further permission supplied the original perform is attributed as specified around the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).two water content, volume, or frequency of stools.11 A reduce in consistency (ie, soft or liquid) and a rise inside the frequency of bowel movements to three stools per day have frequently been applied as a definition for epidemiological investigations. Determined by a community-based study viewpoint, diarrhea is defined as at the very least three or more loose stools inside a 24-hour period.12 A diarrheal episode is deemed as the passage of 3 or a lot more loose or liquid stools in 24 hours prior to presentation for care, which is regarded as essentially the most practicable in young children and adults.13 Nevertheless, prolonged and persistent diarrhea can last among 7 and 13 days and a minimum of 14 days, respectively.14,15 The disease is extremely sensitive to climate, displaying seasonal variations in many web pages.16 The climate sensitivity of diarrheal illness is constant with observations from the direct effects of climate variables around the causative agents. Temperature and relative humidity possess a direct influence on the price of replication of bacterial and protozoan pathogens and around the survival of enteroviruses within the environment.17 Health care journal.pone.0169185 seeking is recognized to become a outcome of a complex behavioral approach that is influenced by various factors, such as socioeconomic and demographic and qualities, perceived want, accessibility, and service availability.