Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This short article is distributed beneath the terms on the Creative Commons Attribution-NonCommercial three.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, purchase CEP-37440 reproduction and distribution from the function without having additional permission offered the original operate is attributed as specified around the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).2 water content, volume, or frequency of stools.11 A decrease in consistency (ie, soft or liquid) and an increase inside the frequency of bowel movements to three stools per day have typically been applied as a definition for epidemiological investigations. Based on a community-based study perspective, diarrhea is defined as at the least three or far more loose stools within a 24-hour period.12 A diarrheal episode is thought of as the passage of 3 or extra loose or liquid stools in 24 hours prior to presentation for care, which can be DM-3189 biological activity regarded one of the most practicable in children and adults.13 Even so, prolonged and persistent diarrhea can final amongst 7 and 13 days and at least 14 days, respectively.14,15 The disease is extremely sensitive to climate, displaying seasonal variations in several websites.16 The climate sensitivity of diarrheal disease is consistent with observations with the direct effects of climate variables around the causative agents. Temperature and relative humidity have a direct influence on the rate of replication of bacterial and protozoan pathogens and around the survival of enteroviruses inside the environment.17 Well being care journal.pone.0169185 in search of is recognized to be a result of a complicated behavioral procedure that may be influenced by several factors, including socioeconomic and demographic and characteristics, perceived need to have, accessibility, and service availability.Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This short article is distributed under the terms in the Inventive Commons Attribution-NonCommercial three.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, reproduction and distribution of your work without having further permission offered the original operate is attributed as specified around the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).two water content, volume, or frequency of stools.11 A decrease in consistency (ie, soft or liquid) and an increase within the frequency of bowel movements to three stools each day have typically been utilised as a definition for epidemiological investigations. According to a community-based study viewpoint, diarrhea is defined as at the least three or a lot more loose stools within a 24-hour period.12 A diarrheal episode is viewed as because the passage of three or a lot more loose or liquid stools in 24 hours before presentation for care, that is considered the most practicable in youngsters and adults.13 Nonetheless, prolonged and persistent diarrhea can final amongst 7 and 13 days and at the very least 14 days, respectively.14,15 The illness is hugely sensitive to climate, displaying seasonal variations in quite a few web sites.16 The climate sensitivity of diarrheal disease is constant with observations of the direct effects of climate variables on the causative agents. Temperature and relative humidity possess a direct influence on the price of replication of bacterial and protozoan pathogens and on the survival of enteroviruses within the atmosphere.17 Wellness care journal.pone.0169185 searching for is recognized to be a outcome of a complicated behavioral procedure that may be influenced by several elements, including socioeconomic and demographic and traits, perceived will need, accessibility, and service availability.