S article could be found on the web at journal.frontiersin.orgarticle.fpsyg..full#supplementarymaterialFrontiers in Psychology www.frontiersin.orgApril Volume ArticleBarredaTarrazona et al.Cooperative Behavior in Prisoner’s Dilemma
ORIGINAL Investigation ARTICLEPSYCHIATRYpublished December .fpsyt.Enhanced dopamine D and BDNF signaling within the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated miceThomas F.Tropea , , Zeeba D.Kabir , , Gagandeep Kaur , Anjali M.Rajadhyaksha , and Barry E.Kosofsky , Division of Pediatric Neurology, Division of Pediatrics, Weill Cornell Medical College, New York, NY, USA College of Osteopathic Medicine, University of New England, Biddeford, ME, USA Graduate System in Neurosciences, Weill Cornell Medical College, New York, NY, USA College of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USAEdited by Linda Mayes, Yale University, USA Reviewed by Katerina Maniadaki, Technological Educational Institute of Athens, Greece Diana DowEdwards, State University of New York, USA Correspondence Barry E.Kosofsky , Division of Kid Neurology, Weill Cornell Medical CollegeNew York Presbyterian Hospital, East th Street, Box , New York, NY , USA.email [email protected] function from our group and other people using animal models have demonstrated longlasting structural and functional alterations inside the mesocorticostriatal dopamine pathway following prenatal cocaine (PCOC) treatment.We’ve shown that PCOC therapy final results in augmented Dinduced cyclic AMP (cAMP) and cocaineinduced immediateearly gene expression in the striatum of adult mice.Within this study we further examined basal too as cocaine or Dinduced activation of a set of molecules known to be mediators of neuronal plasticity following psychostimulant therapy, with emphasis inside the dorsal striatum (Str) and nucleus accumbens (NAc) of PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21563520 adult mice exposed to cocaine in utero.Basally, within the Str of PCOC treated mice there were significantly higher levels of CREB and Ser PCREB Thr PDARPP and GluA and Ser PGluA when compared to prenatal saline (PSAL) treated mice.In the NAc there have been significantly higher basal levels of CREB and Ser PCREB, ThrTyr PERK, and Ser PGluA.Following acute administration of cocaine ( mgkg, i.p) or D agonist (SKF ; mgkg, i.p) there had been drastically larger levels of Ser PCREB, Thr PDARPP, and ThrTyr PERK in the Str that were evident in all animals tested.However, these cocaineinduced increases in phosphorylation have been considerably augmented in PCOC mice compared to PSAL mice.In sharp contrast towards the observations within the Str, in the NAc, acute administration of cocaine or D agonist significantly elevated PCREB and PERK in PSAL mice, a response that was not evident in PCOC mice.Examination of Ser PGluA SC75741 Caspase revealed that cocaine or D agonist significantly increased levels in PSAL mice, but considerably decreased levels within the PCOC mice in both the Str and NAc.We also examined changes in brainderived neurotrophic issue (BDNF).Our research revealed considerably greater levels of your BDNF precursor, proBDNF and 1 of its receptors, TrkB inside the Str of PCOC mice , in comparison to PSAL mice.These benefits suggest a persistent upregulation of molecules vital to D and BDNF signaling in the Str of adult mice exposed to cocaine in utero.These molecular adaptations may underlie components in the behavioral deficits evident in exposed animals along with a subset of exposed h.