An 50 of young children up to six years of age possess a headache duration shorter than 30 minutes, therefore they couldn’t be classified either in migraine or in tension-type headache [3]. A number of research have shown the primary function played by psychological factors in determining the severity of migraine in young children [4]. Consequently, a psychological examination is frequently mandatory, as a part of the initial assessment in the patient. Lastly, when assessing a kid with principal headache, attainable comorbidities need to be never forgotten, because addressing them can represent a critical point for the therapy [5].References 1. Papetti L, Capuano A, Tarantino S, Vigevano F, Valeriani M. Headache as an emergency in young children and adolescents. Curr Pain Headache Rep 2015;19:three. 2. Balestri M, Papetti L, Maiorani D, Capuano A, Tarantino S, Battan B, Vigevano F, Valeriani M. Capabilities of aura in paediatric migraine diagnosed making use of the and ICHD 3III beta criteria. Cephalalgia, submitted. three. Torriero R, Capuano A, Mariani R, Frusciante R, Tarantino S, Papetti L, Vigevano F, Valeriani M. Diagnosis of key headache in children younger than six years: A clinical challenge. Cephalalgia 2017;37:947-954. 4. ge A, Yalin O Chronic Migraine in Kids and Adolescents. Curr Pain Headache Rep 2016;20:14. 5. Guidetti V, Arruda M, ge A. Headache and comorbidities in childhood and adolescence. Springer,In this presentation, preclinical data will be presented showing that chronic exposure to eletriptan or indomethacin alter trigeminal ganglion gene expression patterns broadly and to a equivalent extend. Remarkably, Dihydroxyacetone phosphate hemimagnesium qualitative transcriptomic analysis reveals that prolonged exposure for the two various symptomatic drugs triggers virtually identical, elevated expression of numerous genes coding for proteins involved in headache pathogenesis for instance neuropeptides, their cognate receptors, TRP channels, prostanoid and NO synthesizing enzymes. These findings will probably be correlated together with the clinical elements of MOH. S45 The really low calorie ketogenic diet plan within the clinical practice Roberta Ienca, Simona Sodano 1 Department of Experimental Medicine, Medical Pathophysiology, meals science and endocrinology section, Sapienza University, Rome, 00100, Italy Correspondence: Roberta Ienca ([email protected]) The Journal of Headache and Discomfort 2017, 18(Suppl 1):S45 Background The really low calorie diet program (VLCD) is really a dietetic regimen characterized by a each day energetic intake 800 Kcalday, also known as “simulated fasting”. The dramatic caloric restriction promotes the fat metabolism, mimicking the starvation, even though meals replacements ad hoc developed accounts for crucial nutrients, avoiding the malnutrition. Because of the extreme caloric restriction, this type of diet is quite successful in weight reduction, nevertheless, that characteristic also would be the major limit of VLCD, since it really is probable to follow this type of dietetic regimen for a extremely restricted period (ordinarily 312 weeks). Components and methods Based on macronutrients intake, it’s doable to divide all the VLCDs in two sub-groups: ketogenic (VLCKD) and non-ketogenic diets. The VLCKD is characterized by low-carbohydrate (about 30 gday carbohydrates), low-fat (fixed 15 g lipids), and slightly highprotein (1.0.4 gkg of excellent body weight), divided in four each day meals consisting of dietary items created ad hoc and nutraceutical integrators (Table 1). Salads are permitted ad libitum dressed having a spoonful of olive oil. The non-ketogenic VLCD is characterized.