Ters, CSIR-HRDC Campus Sector 19, Kamala Nehru Nagar, Ghaziabad 201002, India Correspondence: [email protected]; Tel.: +61-3-9925-Citation: Jakku, R.K.; Mirzadeh, N.; Priv , S.H.; Reddy, G.; Vardhaman, A.K.; Lingamallu, G.; Trivedi, R.; Bhargava, S.K. TetraphenylethyleneSubstituted Bis(thienyl)imidazole (DTITPE), An Effective Molecular Sensor for the CV-6209 Description detection and Quantification of Fluoride Ions. Chemosensors 2021, 9, 285. https:// doi.org/10.3390/chemosensors9100285 Academic Editors: Valerio Vignoli and Enza PanzardiAbstract: Fluoride ion plays a pivotal role inside a array of biological and chemical applications having said that excessive exposure may cause extreme kidney and gastric issues. A basic and selective molecular sensor, 4,5-di(thien-2-yl)-2-(4-(1,two,2-triphenylvinyl)-phenyl)-1H-imidazole, DTITPE, has been synthesized for the detection of fluoride ions, with detection limits of 1.37 10- 7 M and two.67 10-13 M, determined by UV-vis. and fluorescence spectroscopy, respectively. The variation within the optical properties from the molecular sensor inside the presence of fluoride ions was explained by an intermolecular charge transfer (ICT) course of action among the bis(thienyl) and tetraphenylethylene (TPE) moieties upon the formation of a N-H–F- hydrogen bond of your imidazole proton. The sensing mechanism exhibited by DTITPE for fluoride ions was confirmed by 1 H NMR spectroscopic studies and density functional theory (DFT) calculations. Test strips coated with the molecular sensor can detect fluoride ions in THF, undergoing a colour modify from white to yellow, which is often observed together with the naked eye, showcasing their prospective real-world application. Keyword phrases: bis(thienyl) imidazole; tetraphenylethylene; molecular sensor; fluoride anion; fluorescenceReceived: 23 July 2021 Accepted: 28 September 2021 Published: 6 OctoberPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in Apremilast D5 web published maps and institutional affiliations.1. Introduction The detection and recognition of anionic analytes has developed into an really active research field in recent years [14]. Anions play a essential part within a array of biological and chemical processes, and their detection, even at really low concentrations, has been the motivation for continuous improvement in sensor development over the last handful of decades [15,16]. In line with the earlier literature, the probable toxic dose (PTD) of fluoride was defined at 5 mg/kg of physique mass. The PTD could be the minimal dose that could trigger really serious and life-threatening indicators and symptoms which demand quick treatment and hospitalization [17]. The fluoride anion, getting the smallest ionic radii, really hard Lewis basic nature and high charge density, has emerged as an attractive subject for sensor design and style because of its association having a wide range of organic, medicinal, and technological procedures. In addition, fluoride ions play a important part in dental health [18] and has been utilized for the remedy of osteoporosis [191] and for military uses, like the refinement of uranium for nuclear weapons [22]. It is readily absorbed by the human bodyCopyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access post distributed below the terms and situations of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).Chemosensors 2021, 9, 285. https://doi.org/10.3390/chemosensorshttps://www.mdpi.com/journal/chemosensorsChemosensors 20.