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Redox Biology 12 (2017) 657sirtuininhibitorContents lists accessible at ScienceDirectRedox Biologyjournal homepage: www.elsevier/locate/redoxResearch paperParticular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin’s neuroprotective activity soon after focal cerebral ischemia in miceUlkan Kilica,b, Ahmet Burak Caglayana,c, Mustafa Caglar Bekera,c, Mehmet Yalcin Gunala,c, Berrak Caglayana,c, Esra Yalcina,c, Taha Kelestemura,c, Reyhan Zeynep Gundogdua,c, Burak Yuluga,d, Bayram Yilmazf, Bilal Ersen Kermana,e, Ertugrul Kilica,c,aMARKRegenerative and Restorative Health-related Analysis Center, Istanbul Medipol University, Istanbul, Turkey Dept. of Healthcare Biology, Istanbul Medipol University, Turkey Dept. of Physiology, Istanbul Medipol University, Turkey d Dept. of Neur.