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Yang et al. Lipids in Wellness and Disease 2013, 12:154 http://www.lipidworld/content/12/1/RESEARCHOpen AccessHypolipidemic effect of gypenosides in experimentally induced hypercholesterolemic ratsYue-Hui Yang*, Jun Yang and Qing-Hua JiangAbstractBackground: To investigate the anti-hyperlipidemic effect of gynosaponins (GPs) in hyperlipidemic rats induced by high lipid diet program. Procedures: Animal model of hyperlipidemia was established by high-fat and high-cholesterol diet regime. Rats were randomly divided into six groups, except the standard and model groups, rats in GPs groups had been everyday administered intragastrically with GPs (50, one hundred, and 200 mg/kg), and rats in simvastatin group have been everyday administered intragastrically with simvastatin (ten mg/kg).L-Phenylalanine It was measured that the contents of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) inside the serum, TG and TC inside the liver in the course of this experiment, respectively.Rosuvastatin Calcium The left lobe of liver was observed by histopathological staining, and also the immunohistochemical staining was made use of to observe the effects on the impact of GPs on liver functions.PMID:23310954 Benefits: Compared with the model group, GPs groups could remarkably reduce the content of lipids, GSH-Px, SOD, CAT and MDA in the serum and TC and TG within the liver of the hyperlipidemic rats. The pathomorphological outcomes of hepatic tissue showed that fatty degeneration and inflammatory reaction of GPs groups were lightened compared with the model group. Conclusions: The results show that GPs has great effects on the therapy of hyperlipidemia induced by high lipid diet program in rats. The probable anti-hyperlipidemia mechanism possibly those GPs can regulate the disorder of lipid metabolism also as ameliorate hep.