H, CH2), four.27.22 (m, 10H, CH2), 2.58 (t, J = 2.four Hz, 1H, CCH), 1.99.92 (m, 10H, CH2), 1.60.53 (m, 10H, CH2), 1.50.43 (m, 10H, CH2), 0.98 (t, J = 7.6Hz, 15H, CH3); 13C NMR (CDCl3, one hundred MHz) 149.2, 149.0, 148.8, 146.7, 124.7, 123.9, 123.5, 123.4, 123.three, 123.2, 109.eight, 107.4, 107.2, 107.0, 106.7, 106.5, 78.9, 75.9, 69.7, 69.five, 69.3, 57.8, 29.1, 29.0, 28.4, 28.3, 22.six, 14.1; anal. calcd for C46H64O6: C, 77.49; H, 9.05; found: C, 77.41; H, 9.00. Trimer 4: A mixture of two (252 mg, 0.3 mmol) and Co2(CO)8 (10 mg, 0.03 mmol) in dioxane (20 mL) was stirred under reflux for 24 h beneath an argon atmosphere, then cooled to space temperature. The organic phase was extracted with CH2Cl2, dried over MgSO4 and the solvent was removed. The crude solution was purified by column chromatography on silica gel eluted with CH2Cl2/hexane (3:1 in volume), and then re-crystal-lized from ethanol affording a white solid (178 mg, 0.21 mmol, 71 ). 1H NMR (CDCl3, TMS, 600 MHz) eight.02.00 (m, 3H, ArH), 7.81.71 (m, 15H, ArH), 7.06 (d, J = 3.six Hz, 1H, ArH), six.97 (s, 1H, ArH), six.95 (d, J = three.9 Hz, 1H, ArH), six.83 (the 1,three,5-trisubstituted benzene core), 4.23.18 (m, 30H, CH2), two.66 (t, J = 7.five Hz, 6H, CH 2 ), two.61.55 (m, 6H, CH 2 ), 1.97.81 (m, 36H, CH2), 1.66.34 (m, 90H, CH2), 0.99.95 (m, 45H, CH3); 13C NMR (CDCl3, 100 MHz) 172.1, 149.5, 149.three, 149.0, 148.7, 148.6, 140.3, 140.two, 139.6, 137.six, 129.two, 129.0, 127.8, 125.eight, 124.five, 123.3, 123.0, 122.9, 116.6, 107.7, 107.0, 106.6, 106.three, 105.8, 69.7, 69.3, 69.1, 68.7, 35.7, 34.2, 32.9, 32.4, 31.7, 31.5, 30.0, 29.9, 29.6, 29.five, 29.four, 29.2, 29.1, 28.four, 28.three, 25.2, 22.6, 14.two; anal. calcd for C162H234O21: C, 77.29; H, 9.37; discovered: C, 77.61; H, 9.39. Trimer 5a: Trimer 5a was synthesized by the identical technique as four, which afforded a colorless oily product (186 mg, 0.RF9 23 mmol, 56 ).Nimodipine 1H NMR (CDCl3, TMS, 600 MHz) 7.PMID:23847952 82 (s, 18H, ArH), 7.04 (d, J = three.9 Hz, 1H, ArH), six.95 (s, 1H, ArH), 6.93 (d, J = 3.9 Hz, 1H, ArH), 6.81 (the 1,3,5-trisubstituted benzene core), four.23.21 (m, 36H, CH2), 2.58.52 (m, 6H, CH2), 1.97.91 (m, 36H, CH2), 1.58.35 (m, 96H, CH2), 0.98.95 (m, 45H, CH three ); 13 C NMR (CDCl three , 100 MHz) 149.1, 149.0, 148.9, 148.eight, 148,7, 140.three, 140.1, 137.six, 129.2, 128.9, 125.7, 123.7, 123.six, 123.five, 123.four, 107.3, 107.2, 107.1, 107.0, 69.six, 35.7, 32.8, 32.4, 31.7, 31.five, 31.four, 30.0, 29.9, 29.7, 29.six, 29.5, 29.1, 28.four, 26.3, 22.6, 14.1; anal. calcd for C162H240O18: C, 78.60; H, 9.77; discovered: C, 78.55; H, 9.79. Trimer 5b: 5b was synthesized by the identical method as four, which afforded a white solid (195 mg, 0.26 mmol, 66 ). 1H NMR (CDCl3, TMS, 600 MHz) 7.82.73 (m, 18H, ArH), 7.22 (d, J = 3.9 Hz, 1H, ArH), 7.18 (s, 1H, ArH), 7.09 (dd, J = three.9 Hz, J = 0.9 Hz, 1H, ArH), 7.03 (the 1,3,5-trisubstituted benzene core), 4.28.13 (m, 36H, CH2), 3.0 (t, J = 7.9 Hz, 4H, CH2), 2.88 (t, J = eight.0 Hz, 2H, CH2), 2.28.18 (m, 6H, CH2), 1.97.85 (m, 30H, CH2), 1.59.35 (m, 60H, CH2), 0.99.87 (m, 45H, CH3); 13C NMR (CDCl3, 100 MHz) 148.9, 148.eight, 148.7, 148.six, 139.eight, 139.7, 137.2, 129.8, 129.6, 126.four, 123.6, 123.5, 123.four, 107.two, 107.1, 106.9, 106.8, 69.six, 69.5, 69.four, 69.three, 68.7, 68.5, 32.0, 31.9, 31.three, 31.2, 31.1, 29.7, 29.two, 29.0, 28.6, 28.4, 22.six, 14.1; anal. calcd for C144H204O18: C, 77.80; H, 9.25; identified: C, 77.83; H, 9.26. Trimer 5c: Trimer 5c was synthesized by the exact same system as 4, which afforded a white strong (117 mg, 0.16 mmol, 36 ). 1H NMR (CDCl3, TMS, 600 MHz) 7.95.60 (m, 21H, ArH), 5.65 (s, 4H, CH2), five.37 (s, 2H, CH2), four.24.12 (m, 22H, CH2), 4.07.03 (m, 4H, CH2), 3.97.9.