Product Name :
Anti-Claudin-18, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human/Cynomolgus
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-Claudin-18, Human antibody is designed for detecting human Claudin-18 specifically. Anti-Claudin-18, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc. Based on ELISA, Anti-Claudin-18, Human antibody reacts with human Claudin-18, and has reactivity with cynomolgus Claudin-18. | Immunogen: Recombinant human Claudin-18 | Host: Alpaca pacous | Isotype: VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation) | Conjugate: Unconjugated | Specificity: Human Claudin-18 | Cross-Reactivity: Cross-reactivity with cynomolgus Claudin-18 | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.Domperidone 5), 0.Iloprost 05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C | Background:Claudin-18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions. Claudins exhibit specific patterns of expression in different tissues. Claudin-18 is specifically expressed in the stomach and lung.PMID:24268253 Claudin-18 has two alternatively spliced variants, Claudin-18.1 and Claudin-18.2. Claudin-18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas Claudin-18.1 is lung specific. Altered Claudin-18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm.Using antibody with Fc(mutation), the background from Fc receptors will be eliminated.
Description2 :
Anti-Claudin-18, Human antibody is designed for detecting human Claudin-18 specifically. Anti-Claudin-18, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc. Based on ELISA, Anti-Claudin-18, Human antibody reacts with human Claudin-18, and has reactivity with cynomolgus Claudin-18.
Immunogen:
Recombinant human Claudin-18
Host :
Alpaca pacous
Isotype:
VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation)
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.