Product Name :
DIM-C-pPhOCH3
Description:
DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.
CAS:
33985-68-1
Molecular Weight:
352.43
Formula:
C24H20N2O
Chemical Name:
3-[(1H-indol-3-yl)(4-methoxyphenyl)methyl]-1H-indole
Smiles :
COC1C=CC(=CC=1)C(C1=CNC2C=CC=CC=21)C1=CNC2C=CC=CC=21
InChiKey:
ZCCMKJAXOIFTHH-UHFFFAOYSA-N
InChi :
InChI=1S/C24H20N2O/c1-27-17-12-10-16(11-13-17)24(20-14-25-22-8-4-2-6-18(20)22)21-15-26-23-9-5-3-7-19(21)23/h2-15,24-26H,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.|Product information|CAS Number: 33985-68-1|Molecular Weight: 352.43|Formula: C24H20N2O|Chemical Name: 3-[(1H-indol-3-yl)(4-methoxyphenyl)methyl]-1H-indole|Smiles: COC1C=CC(=CC=1)C(C1=CNC2C=CC=CC=21)C1=CNC2C=CC=CC=21|InChiKey: ZCCMKJAXOIFTHH-UHFFFAOYSA-N|InChi: InChI=1S/C24H20N2O/c1-27-17-12-10-16(11-13-17)24(20-14-25-22-8-4-2-6-18(20)22)21-15-26-23-9-5-3-7-19(21)23/h2-15,24-26H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 33.3 mg/mL (94.49 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pyrazinamide} site|{Pyrazinamide} Antibiotic|{Pyrazinamide} Technical Information|{Pyrazinamide} References|{Pyrazinamide} manufacturer|{Pyrazinamide} Autophagy} |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein.{{Degarelix} site|{Degarelix} Apoptosis|{Degarelix} Biological Activity|{Degarelix} Formula|{Degarelix} manufacturer|{Degarelix} Epigenetics} DIM-C-pPhOCH3 also induces Nur77-independent apoptosis.PMID:24238415 DIM-C-pPhOCH3 (10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH3.|In Vivo:|DIM-C-pPhOCH3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls.|Products are for research use only. Not for human use.|