Product Name :
TDCPP
Description:
TDCPP is a chlorinated analog of tris(2,3-dibromopropyl)phosphate (Tris) which is one of the most detected organophosphorus flame retardants (OPFRs) in the environment.
CAS:
13674-87-8
Molecular Weight:
430.90
Formula:
C9H15Cl6O4P
Chemical Name:
tris(1,3-dichloropropan-2-yl) phosphate
Smiles :
O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CCl
InChiKey:
ASLWPAWFJZFCKF-UHFFFAOYSA-N
InChi :
InChI=1S/C9H15Cl6O4P/c10-1-7(2-11)17-20(16,18-8(3-12)4-13)19-9(5-14)6-15/h7-9H,1-6H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TDCPP is a chlorinated analog of tris(2,3-dibromopropyl)phosphate (Tris) which is one of the most detected organophosphorus flame retardants (OPFRs) in the environment.|Product information|CAS Number: 13674-87-8|Molecular Weight: 430.90|Formula: C9H15Cl6O4P|Chemical Name: tris(1,3-dichloropropan-2-yl) phosphate|Smiles: O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CCl|InChiKey: ASLWPAWFJZFCKF-UHFFFAOYSA-N|InChi: InChI=1S/C9H15Cl6O4P/c10-1-7(2-11)17-20(16,18-8(3-12)4-13)19-9(5-14)6-15/h7-9H,1-6H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 62.5 mg/mL (145.05 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Exposure to TDCPP does not significantly affect cell viability until at concentration >68 μg/mL. HCECs show a 16% cell viability loss after exposing to 136 μg/mL TDCPP. Moreover, TDCPP induces a sharp decrease in viable cells (87%) after exposing to ≥272 μg/mL TDCPP.{{Dabrafenib} MedChemExpress|{Dabrafenib} MAPK/ERK Pathway|{Dabrafenib} Biological Activity|{Dabrafenib} Formula|{Dabrafenib} manufacturer|{Dabrafenib} Autophagy} Based on cell viability, the LC50 value for TDCPP is 202 μg/mL using a nonlinear regression.{{Mitotane} site|{Mitotane} Apoptosis|{Mitotane} Technical Information|{Mitotane} References|{Mitotane} manufacturer|{Mitotane} Epigenetics} Compare to controls, TDCPP-exposed cells exhibit a concentration-dependent increase in apoptosis.PMID:24883330 Anti-apoptotic Bcl-2 protein expression is increased to 1.4 fold after exposing to 2 μg/mL TDCPP, 1.2-folds at 20 μg/mL but dynamically decreased to 0.4 fold at 200 μg/mL compare to control. The caspase-3 activity is increased to 2.1 folds of the control at 200 μg/mL TDCPP. TDCPP inhibits cell growth at lower concentrations (IC50 of 27 μM), while cell viability and toxicity are affected at higher concentrations (IC50 of 171 μM and 168 μM, respectively).|Products are for research use only. Not for human use.|