Product Name :
CMP-5 hydrochloride
Description:
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected.
CAS:
1030021-40-9
Molecular Weight:
351.87
Formula:
C21H22ClN3
Chemical Name:
[(9-ethyl-9H-carbazol-3-yl)methyl][(pyridin-2-yl)methyl]amine hydrochloride
Smiles :
Cl.CCN1C2=CC=C(CNCC3=CC=CC=N3)C=C2C2=CC=CC=C12
InChiKey:
LTMOFUKBECEABM-UHFFFAOYSA-N
InChi :
InChI=1S/C21H21N3.ClH/c1-2-24-20-9-4-3-8-18(20)19-13-16(10-11-21(19)24)14-22-15-17-7-5-6-12-23-17;/h3-13,22H,2,14-15H2,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fmoc-Asp(OtBu)-OH} web|{Fmoc-Asp(OtBu)-OH} {Amino Acid Derivatives}|{Fmoc-Asp(OtBu)-OH} TGF-beta/Smad|{Fmoc-Asp(OtBu)-OH} Purity & Documentation|{Fmoc-Asp(OtBu)-OH} In Vitro|{Fmoc-Asp(OtBu)-OH} supplier}
Shelf Life:
≥12 months if stored properly.{{AAA} site|{AAA} Technical Information|{AAA} Data Sheet|{AAA} custom synthesis|{AAA} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23937941
Additional information:
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected.|Product information|CAS Number: 1030021-40-9|Molecular Weight: 351.87|Formula: C21H22ClN3|Chemical Name: [(9-ethyl-9H-carbazol-3-yl)methyl][(pyridin-2-yl)methyl]amine hydrochloride|Smiles: Cl.CCN1C2=CC=C(CNCC3=CC=CC=N3)C=C2C2=CC=CC=C12|InChiKey: LTMOFUKBECEABM-UHFFFAOYSA-N|InChi: InChI=1S/C21H21N3.ClH/c1-2-24-20-9-4-3-8-18(20)19-13-16(10-11-21(19)24)14-22-15-17-7-5-6-12-23-17;/h3-13,22H,2,14-15H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CMP-5 (0-100 μM; 24-72 hours) is selectively toxic to lymphoma cells, but shows a limited toxicity to normal resting B lymphocytes even after prolonged incubation. CMP-5 (40 μM; 24 hours) decreases p-BTK and pY(416)SRC expression in 60A cells when it compares to the DMSO-treated group. CMP-5 (0-40 μM; 24 hours) preferentially suppresses the proliferation of human Th1 cells over Th2 cells (43 versus 9% inhibition, respectively). The sensitivity of Th1 cells over Th2 cells to PRMT5 inhibition is different, the IC50 values are 26.9 μM and 31.6 μM in human Th1 cells and Th2 cells, respectively. CMP-5 (25 μM; 24 hours) alone inhibits mouse Th1 cell proliferation by 91%, when added different doses IL-2, IL-2 enhances proliferation and reaches a peak at 5 ng/ml.|Products are for research use only. Not for human use.|