Product Name :
2OH-BNPP1
Description:
2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.
CAS:
833481-73-5
Molecular Weight:
297.35
Formula:
C16H19N5O
Chemical Name:
2-({4-amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl}methyl)phenol
Smiles :
CC(C)(C)N1N=C(CC2=CC=CC=C2O)C2=C(N)N=CN=C12
InChiKey:
LWLCFWPPMNPMOI-UHFFFAOYSA-N
InChi :
InChI=1S/C16H19N5O/c1-16(2,3)21-15-13(14(17)18-9-19-15)11(20-21)8-10-6-4-5-7-12(10)22/h4-7,9,22H,8H2,1-3H3,(H2,17,18,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.|Product information|CAS Number: 833481-73-5|Molecular Weight: 297.35|Formula: C16H19N5O|Chemical Name: 2-({4-amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl}methyl)phenol|Smiles: CC(C)(C)N1N=C(CC2=CC=CC=C2O)C2=C(N)N=CN=C12|InChiKey: LWLCFWPPMNPMOI-UHFFFAOYSA-N|InChi: InChI=1S/C16H19N5O/c1-16(2,3)21-15-13(14(17)18-9-19-15)11(20-21)8-10-6-4-5-7-12(10)22/h4-7,9,22H,8H2,1-3H3,(H2,17,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (336.{{Mitotane} web|{Mitotane} Apoptosis|{Mitotane} Purity & Documentation|{Mitotane} In Vitro|{Mitotane} custom synthesis|{Mitotane} Epigenetics} 30 mM).{{Phenacetin} site|{Phenacetin} COX|{Phenacetin} Technical Information|{Phenacetin} Description|{Phenacetin} supplier|{Phenacetin} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23554582 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.|In Vivo:|2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.|Products are for research use only. Not for human use.|