Fri. Dec 20th, 2024

Product Name :
LDN-212320

Description:
LDN-0212320 Maleate is a novel activator of glutamate transporter EAAT2 translation.

CAS:
894002-50-7

Molecular Weight:
409.46

Formula:
C21H19N3O4S

Chemical Name:
3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine maleate

Smiles :
CC1=CC=CC=C1CSC1=CC=C(N=N1)C1=CC=CC=N1.OC(=O)/C=C\C(O)=O

InChiKey:
QIGJQEQXFAVIPF-BTJKTKAUSA-N

InChi :
InChI=1S/C17H15N3S.C4H4O4/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15;5-3(6)1-2-4(7)8/h2-11H,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
LDN-0212320 Maleate is a novel activator of glutamate transporter EAAT2 translation.{{Scutellarin} medchemexpress|{Scutellarin} Akt|{Scutellarin} Technical Information|{Scutellarin} Description|{Scutellarin} custom synthesis|{Scutellarin} Autophagy} |Product information|CAS Number: 894002-50-7|Molecular Weight: 409.46|Formula: C21H19N3O4S|Synonym:|LDN-0212320|HY-12741|894002-50-7|LDN-212320|LDN 212320|3-[(2-methylphenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine|3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine|F2005-0208|C17H15N3S|3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine|CHEMBL1834164|SCHEMBL14685055|AOB2666|SYN5193|LDN/OSU-0212320|ZINC4358191|3771AH|AKOS024458486|CS-3927|MCULE-7001577076|AS-16553|SR-01000909725|3-(2-methylbenzylthio)-6-(pyridin-2-yl)pyridazine|SR-01000909725-1|OSU-0212320|Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine maleate|Smiles: CC1=CC=CC=C1CSC1=CC=C(N=N1)C1=CC=CC=N1.OC(=O)/C=C\C(O)=O|InChiKey: QIGJQEQXFAVIPF-BTJKTKAUSA-N|InChi: InChI=1S/C17H15N3S.C4H4O4/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15;5-3(6)1-2-4(7)8/h2-11H,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-|Technical Data|Appearance: Solid Power.{{Reverse T3} medchemexpress|{Reverse T3} Thyroid Hormone Receptor|{Reverse T3} Technical Information|{Reverse T3} Formula|{Reverse T3} supplier|{Reverse T3} Autophagy} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24025603 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vivo:|LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior. LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC. LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC.|References:|Arendowski A, Ruman T. Laser Desorption/Ionisation Mass Spectrometry Imaging of European Yew (Taxus baccata) on Gold Nanoparticle-enhanced Target. Phytochem Anal. 2017 May 19. doi: 10.1002/pca.2693. [Epub ahead of print] PubMed PMID: 28523824.Hirahara M, Fujiwara N, Seo K. Novel trigeminal slice preparation method for studying mechanisms of nociception transmission. J Neurosci Methods. 2017 May 15. pii: S0165-0270(17)30146-2. doi: 10.1016/j.jneumeth.2017.05.019. [Epub ahead of print] PubMed PMID: 28522210.Kim SY, Park S, Yoo S, Rho JK, Jun ES, Chang S, Kim KK, Kim SC, Kim I. Downregulation of X-linked inhibitor of apoptosis protein by ‘7-Benzylidenenaltrexone maleate’ sensitizes pancreatic cancer cells to TRAIL-induced apoptosis. Oncotarget. 2017 May 12. doi: 10.18632/oncotarget.17841. [Epub ahead of print] PubMed PMID: 28521307.Mohammadi Z, Jafarzadeh H, Shalavi S, Kinoshita JI. Unusual Root Canal Irrigation Solutions. J Contemp Dent Pract. 2017 May 1;18(5):415-420. PubMed PMID: 28512283.Products are for research use only. Not for human use.|

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