Product Name :
Lys-Nε-SPDB-DM4
Description:
Lys-Nε-SPDB-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody drug conjugate (ADC).
CAS:
1280215-91-9
Molecular Weight:
1026.69
Formula:
C48H72ClN5O13S2
Chemical Name:
(2S)-2-amino-6-{4-[(4-{[(2S)-1-{[(1S,2R,3S,5S,6S,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1¹⁰,¹⁴.0³,⁵]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)carbamoyl}-2-methylbutan-2-yl)disulfanyl]butanamido}hexanoic acid
Smiles :
CC(C)(CCC(=O)N(C)[C@@H](C)C(=O)O[C@H]1CC(=O)N(C)C2=CC(CC(C)=CC=C[C@@H](OC)[C@@]3(O)C[C@H](OC(=O)N3)[C@@H](C)[C@@H]3O[C@@]13C)=CC(OC)=C2Cl)SSCCCC(=O)NCCCC[C@H](N)C(O)=O |t:25,27|
InChiKey:
VUAUZOXSQKWNNO-VFTLTZJBSA-N
InChi :
InChI=1S/C48H72ClN5O13S2/c1-28-15-13-17-36(64-10)48(62)27-35(65-45(61)52-48)29(2)42-47(6,67-42)37(26-40(57)54(8)33-24-31(23-28)25-34(63-9)41(33)49)66-44(60)30(3)53(7)39(56)19-20-46(4,5)69-68-22-14-18-38(55)51-21-12-11-16-32(50)43(58)59/h13,15,17,24-25,29-30,32,35-37,42,62H,11-12,14,16,18-23,26-27,50H2,1-10H3,(H,51,55)(H,52,61)(H,58,59)/b17-13-,28-15-/t29-,30+,32+,35+,36-,37+,42+,47+,48+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bupivacaine} medchemexpress|{Bupivacaine} Calcium Channel|{Bupivacaine} Biological Activity|{Bupivacaine} References|{Bupivacaine} custom synthesis|{Bupivacaine} Cancer}
Shelf Life:
≥12 months if stored properly.{{Ampicillin} medchemexpress|{Ampicillin} Bacterial|{Ampicillin} Protocol|{Ampicillin} Formula|{Ampicillin} custom synthesis|{Ampicillin} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23937941
Additional information:
Lys-Nε-SPDB-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody drug conjugate (ADC).|Product information|CAS Number: 1280215-91-9|Molecular Weight: 1026.69|Formula: C48H72ClN5O13S2|Chemical Name: (2S)-2-amino-6-{4-[(4-{[(2S)-1-{[(1S,2R,3S,5S,6S,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1¹⁰,¹⁴.0³,⁵]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}-1-oxopropan-2-yl](methyl)carbamoyl}-2-methylbutan-2-yl)disulfanyl]butanamido}hexanoic acid|Smiles: CC(C)(CCC(=O)N(C)[C@@H](C)C(=O)O[C@H]1CC(=O)N(C)C2=CC(CC(C)=CC=C[C@@H](OC)[C@@]3(O)C[C@H](OC(=O)N3)[C@@H](C)[C@@H]3O[C@@]13C)=CC(OC)=C2Cl)SSCCCC(=O)NCCCC[C@H](N)C(O)=O |t:25,27||InChiKey: VUAUZOXSQKWNNO-VFTLTZJBSA-N|InChi: InChI=1S/C48H72ClN5O13S2/c1-28-15-13-17-36(64-10)48(62)27-35(65-45(61)52-48)29(2)42-47(6,67-42)37(26-40(57)54(8)33-24-31(23-28)25-34(63-9)41(33)49)66-44(60)30(3)53(7)39(56)19-20-46(4,5)69-68-22-14-18-38(55)51-21-12-11-16-32(50)43(58)59/h13,15,17,24-25,29-30,32,35-37,42,62H,11-12,14,16,18-23,26-27,50H2,1-10H3,(H,51,55)(H,52,61)(H,58,59)/b17-13-,28-15-/t29-,30+,32+,35+,36-,37+,42+,47+,48+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|Products are for research use only. Not for human use.|