Product Name :
ONO-2952
Description:
ONO-2952 is a potent, selective and orally active translocator protein 18 kDa (TSPO) antagonist with Ki of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of noradrenergic system in the brain without the amnesic effect. ONO-2952 has the potential for irritable bowel syndrome treatment.
CAS:
895169-20-7
Molecular Weight:
398.86
Formula:
C22H20ClFN2O2
Chemical Name:
1-[(1’S)-1′-(4-chloro-2-methoxyphenyl)-5′-fluoro-1′,2′,3′,9′-tetrahydrospiro[cyclopropane-1,4′-pyrido[3,4-b]indol]-2′-yl]ethan-1-one
Smiles :
CC(=O)N1CC2(CC2)C2=C(NC3=CC=CC(F)=C32)[C@@H]1C1=CC=C(Cl)C=C1OC
InChiKey:
ZBQMTQGDBFZUBG-NRFANRHFSA-N
InChi :
InChI=1S/C22H20ClFN2O2/c1-12(27)26-11-22(8-9-22)19-18-15(24)4-3-5-16(18)25-20(19)21(26)14-7-6-13(23)10-17(14)28-2/h3-7,10,21,25H,8-9,11H2,1-2H3/t21-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ONO-2952 is a potent, selective and orally active translocator protein 18 kDa (TSPO) antagonist with Ki of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes.{{Efavaleukin alfa} site|{Efavaleukin alfa} Biological Activity|{Efavaleukin alfa} References|{Efavaleukin alfa} manufacturer|{Efavaleukin alfa} Autophagy} ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of noradrenergic system in the brain without the amnesic effect. ONO-2952 has the potential for irritable bowel syndrome treatment.|Product information|CAS Number: 895169-20-7|Molecular Weight: 398.86|Formula: C22H20ClFN2O2|Chemical Name: 1-[(1’S)-1′-(4-chloro-2-methoxyphenyl)-5′-fluoro-1′,2′,3′,9′-tetrahydrospiro[cyclopropane-1,4′-pyrido[3,4-b]indol]-2′-yl]ethan-1-one|Smiles: CC(=O)N1CC2(CC2)C2=C(NC3=CC=CC(F)=C32)[C@@H]1C1=CC=C(Cl)C=C1OC|InChiKey: ZBQMTQGDBFZUBG-NRFANRHFSA-N|InChi: InChI=1S/C22H20ClFN2O2/c1-12(27)26-11-22(8-9-22)19-18-15(24)4-3-5-16(18)25-20(19)21(26)14-7-6-13(23)10-17(14)28-2/h3-7,10,21,25H,8-9,11H2,1-2H3/t21-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Daclatasvir} medchemexpress|{Daclatasvir} Anti-infection|{Daclatasvir} Biological Activity|{Daclatasvir} In Vitro|{Daclatasvir} custom synthesis|{Daclatasvir} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:33322974 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|As for its selectivity for TSPO, ONO-2952 at a concentration of 10 μM showed good selectivity for TSPO against 98 off-targets (In Vivo:|ONO-2952 (0.03-3 mg/kg; oral administration; male Sprague Dawley rats) treatment dose-dependently suppresses restraint stress-induced defecation in rats with brain TSPO occupancy of more than 50%. ONO-2952 also suppresses conditioned fear stress-induced freezing behavior in rats. ONO-2952 inhibits both neurosteroid accumulation and noradrenaline release in the brain of rats exposed to acute stress.|Products are for research use only. Not for human use.|