Product Name :
Rp-8-CPT-cAMPS sodium
Description:
Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.
CAS:
221905-35-7
Molecular Weight:
509.86
Formula:
C16H14ClN5NaO5PS2
Chemical Name:
sodium [(2R, 4aR, 6R, 7R, 7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-oxo-hexahydro-2-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-yl]sulfanide
Smiles :
[Na+].NC1=NC=NC2=C1N=C(SC1C=CC(Cl)=CC=1)N2[C@@H]1O[C@@H]2CO[P@@](=O)([S-])O[C@H]2[C@H]1O
InChiKey:
AWXMSJRRXLCVMW-ALHPSJIMSA-M
InChi :
InChI=1S/C16H15ClN5O5PS2.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(26-15)5-25-28(24,29)27-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,29)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-,28-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Vitamin B12} site|{Vitamin B12} Metabolic Enzyme/Protease|{Vitamin B12} Biological Activity|{Vitamin B12} References|{Vitamin B12} supplier|{Vitamin B12} Autophagy}
Additional information:
Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.|Product information|CAS Number: 221905-35-7|Molecular Weight: 509.86|Formula: C16H14ClN5NaO5PS2|Chemical Name: sodium [(2R, 4aR, 6R, 7R, 7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-oxo-hexahydro-2-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-yl]sulfanide|Smiles: [Na+].NC1=NC=NC2=C1N=C(SC1C=CC(Cl)=CC=1)N2[C@@H]1O[C@@H]2CO[P@@](=O)([S-])O[C@H]2[C@H]1O|InChiKey: AWXMSJRRXLCVMW-ALHPSJIMSA-M|InChi: InChI=1S/C16H15ClN5O5PS2.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(26-15)5-25-28(24,29)27-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,29)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-,28-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Protease Inhibitor Cocktail, Bacteria} MedChemExpress|{Protease Inhibitor Cocktail, Bacteria} Activator|{Protease Inhibitor Cocktail, Bacteria} Purity & Documentation|{Protease Inhibitor Cocktail, Bacteria} Formula|{Protease Inhibitor Cocktail, Bacteria} supplier} |Shelf Life: ≥12 months if stored properly.PMID:33200341 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol. Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2′-O-Me-cAMP and 6-Bnz-cAMP. Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2′-O-Me-cAMP. Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.|References:|Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3′,5′-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91.Roscioni SS, et, al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009 Sep 29;10(1):88.Chaisakul J, et, al. In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring “sudden collapse”. Toxicol Lett. 2012 Sep 3;213(2):243-8.Products are for research use only. Not for human use.|