Product Name :
FTX-6058
Description:
FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia.
CAS:
2490676-18-9
Molecular Weight:
403.41
Formula:
C22H18FN5O2
Chemical Name:
(15R)-21-fluoro-10-(2-methylpyridin-3-yl)-13,17-dioxa-3,5,7,8-tetraazapentacyclo[13.6.1.0⁴,¹².0⁵,⁹.0¹⁸,²²]docosa-1(22),4(12),6,8,10,18,20-heptaene
Smiles :
CC1=NC=CC=C1C1=CC2OC[C@H]3COC4=CC=C(F)C(CNC=2N2C=NN=C21)=C43
InChiKey:
JQBUTSBIFNKJMW-CYBMUJFWSA-N
InChi :
InChI=1S/C22H18FN5O2/c1-12-14(3-2-6-24-12)15-7-19-22(28-11-26-27-21(15)28)25-8-16-17(23)4-5-18-20(16)13(9-29-18)10-30-19/h2-7,11,13,25H,8-10H2,1H3/t13-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia.|Product information|CAS Number: 2490676-18-9|Molecular Weight: 403.41|Formula: C22H18FN5O2|Chemical Name: (15R)-21-fluoro-10-(2-methylpyridin-3-yl)-13,17-dioxa-3,5,7,8-tetraazapentacyclo[13.6.1.0⁴,¹².0⁵,⁹.0¹⁸,²²]docosa-1(22),4(12),6,8,10,18,20-heptaene|Smiles: CC1=NC=CC=C1C1=CC2OC[C@H]3COC4=CC=C(F)C(CNC=2N2C=NN=C21)=C43|InChiKey: JQBUTSBIFNKJMW-CYBMUJFWSA-N|InChi: InChI=1S/C22H18FN5O2/c1-12-14(3-2-6-24-12)15-7-19-22(28-11-26-27-21(15)28)25-8-16-17(23)4-5-18-20(16)13(9-29-18)10-30-19/h2-7,11,13,25H,8-10H2,1H3/t13-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Naxitamab} medchemexpress|{Naxitamab} Purity & Documentation|{Naxitamab} In stock|{Naxitamab} manufacturer|{Naxitamab} Autophagy} |Shelf Life: ≥12 months if stored properly.{{KH7} medchemexpress|{KH7} GPCR/G Protein|{KH7} TGF-beta/Smad|{KH7} Protocol|{KH7} Purity|{KH7} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31755322 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|FTX-6058 inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models.|Products are for research use only. Not for human use.|