Product Name :
Gefitinib D8
Description:
Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.
CAS:
857091-32-8
Molecular Weight:
454.95
Formula:
C22H24ClFN4O3
Chemical Name:
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-{3-[(2, 2, 3, 3, 5, 5, 6, 6-H)morpholin-4-yl]propoxy}quinazolin-4-amine
Smiles :
[2H]C1([2H])N(CCCOC2=CC3=C(NC4=CC(Cl)=C(F)C=C4)N=CN=C3C=C2OC)C([2H])([2H])C([2H])([2H])OC1([2H])[2H]
InChiKey:
XGALLCVXEZPNRQ-IHGLQNJRSA-N
InChi :
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)/i6D2,7D2,9D2,10D2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Stavudine} web|{Stavudine} Nucleoside Antimetabolite/Analog|{Stavudine} Protocol|{Stavudine} Purity|{Stavudine} custom synthesis|{Stavudine} Cancer}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.|Product information|CAS Number: 857091-32-8|Molecular Weight: 454.95|Formula: C22H24ClFN4O3|Synonym:|ZD1839 D8|Chemical Name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-{3-[(2, 2, 3, 3, 5, 5, 6, 6-H)morpholin-4-yl]propoxy}quinazolin-4-amine|Smiles: [2H]C1([2H])N(CCCOC2=CC3=C(NC4=CC(Cl)=C(F)C=C4)N=CN=C3C=C2OC)C([2H])([2H])C([2H])([2H])OC1([2H])[2H]|InChiKey: XGALLCVXEZPNRQ-IHGLQNJRSA-N|InChi: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)/i6D2,7D2,9D2,10D2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Combretastatin A4} MedChemExpress|{Combretastatin A4} Microtubule/Tubulin|{Combretastatin A4} Purity & Documentation|{Combretastatin A4} Purity|{Combretastatin A4} manufacturer|{Combretastatin A4} Epigenetics} |Shelf Life: ≥360 days if stored properly.PMID:33267562 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8.Products are for research use only. Not for human use.|