Product Name :
Oxamflatin
Sequence:
Purity:
≥95% (HPLC)
Molecular Weight:
342.4
Solubility :
Soluble in DMSO, methanol or acetonitrile.
Appearance:
Tan to yellow solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended.{{2624313-15-9} site|{2624313-15-9} Biological Activity|{2624313-15-9} Purity|{2624313-15-9} custom synthesis}
Description:
HDAC inhibitor Potent inhibitor of mammalian HDACs (histone deacetylases) (IC50=15.7nM). Acts as a ligand for the enzyme active site metal ion. Upregulates plasminogen activator inhibitor type 2 (PAI-2) expression with concomitant inhibition of urokinase (u-PA) gene and protein expression in HT-1080 and U-937 cells.{{41575-94-4} site|{41575-94-4} Protocol|{41575-94-4} Data Sheet|{41575-94-4} manufacturer} Elevates the expression of extracellular matrix proteins fibronectin and gelsolin. Induces apoptosis in P-glyoprotein (Pgp) positive and Pgp negative multidrug resistant cells.
CAS :
151720-43-3
Solubility:
Soluble in DMSO, methanol or acetonitrile.PMID:30000414
Formula:
C17H14N2O4S
Additional Information :
| Alternative Name (2E)-5-[3-(Phenylsulfonylamino)phenyl]pent-2-en-4-ynohydroxamic acid | Appearance Tan to yellow solid. | CAS 151720-43-3 | Couple Target HDAC | Couple Type Inhibitor | Formula C17H14N2O4S | MW 342.4 | Purity ≥95% (HPLC) | Solubility Soluble in DMSO, methanol or acetonitrile. | Unit of Measure (UM) mg