Product Name :
SR-717 free acid
Description:
SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity.
CAS:
2375420-34-9
Molecular Weight:
345.26
Formula:
C15H9F2N5O3
Chemical Name:
4,5-difluoro-2-[6-(1H-imidazol-1-yl)pyridazine-3-amido]benzoic acid
Smiles :
OC(=O)C1=CC(F)=C(F)C=C1NC(=O)C1C=CC(=NN=1)N1C=NC=C1
InChiKey:
WEBVQIJGIZVRGA-UHFFFAOYSA-N
InChi :
InChI=1S/C15H9F2N5O3/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22/h1-7H,(H,19,23)(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity.|Product information|CAS Number: 2375420-34-9|Molecular Weight: 345.26|Formula: C15H9F2N5O3|Chemical Name: 4,5-difluoro-2-[6-(1H-imidazol-1-yl)pyridazine-3-amido]benzoic acid|Smiles: OC(=O)C1=CC(F)=C(F)C=C1NC(=O)C1C=CC(=NN=1)N1C=NC=C1|InChiKey: WEBVQIJGIZVRGA-UHFFFAOYSA-N|InChi: InChI=1S/C15H9F2N5O3/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22/h1-7H,(H,19,23)(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.AT6 web |Shelf Life: ≥12 months if stored properly.SCF Protein, Mouse MedChemExpress |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32809360 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SR-717 activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity. SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner.|In Vivo:|SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice. SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming.|Products are for research use only. Not for human use.|