Product Name :
ML133 hydrochloride
Description:
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.
CAS:
1222781-70-5
Molecular Weight:
313.82
Formula:
C19H20ClNO
Chemical Name:
[(4-methoxyphenyl)methyl][(naphthalen-1-yl)methyl]amine hydrochloride
Smiles :
Cl.COC1C=CC(CNCC2=CC=CC3=CC=CC=C23)=CC=1
InChiKey:
NGQIBUUFXDPHKT-UHFFFAOYSA-N
InChi :
InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Carnosol NF-κB
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.|Product information|CAS Number: 1222781-70-5|Molecular Weight: 313.82|Formula: C19H20ClNO|Chemical Name: [(4-methoxyphenyl)methyl][(naphthalen-1-yl)methyl]amine hydrochloride|Smiles: Cl.COC1C=CC(CNCC2=CC=CC3=CC=CC=C23)=CC=1|InChiKey: NGQIBUUFXDPHKT-UHFFFAOYSA-N|InChi: InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 125 mg/mL (398.32 mM). H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Catumaxomab manufacturer |Shelf Life: ≥12 months if stored properly.PMID:33200677 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ML133, which inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5, but exhibits little selectivity against other members of Kir2.x family channels. ML133 has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date.|Products are for research use only. Not for human use.|