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The aim of this short overview would be to trigger a additional essential evaluation of scientific evidence existing in literature on possible hepatotoxicity of Curcuma longa. The revision of sources could be against the latest trend that blames this well-known spice broadly SIRT5 Purity & Documentation employed for PKD3 Biological Activity centuries. Curcuma longa has been utilized throughout human history for various purposes on account of its wide array of biological activity (Sharifi-Rad et al., 2020). Curcumin was found to become the key active element of your extract from the rhizome, called turmeric. Curcumin may be the ingredient responsible for the effects of turmeric as a drug in its long history of use in standard Asian medicine to get a wide wide variety of problems. The Compendium of Sushruta, the foundational text of Ayurveda dating to 250 BCE (Joshi et al., 2017), recommends an ointment containing turmeric, Curcuma longa powdered, to relieve the effects of poisoned meals. It is actually not surprising, hence, that curcumin is currently sold as a dietary supplement and that several clinical trials are ongoing to evaluate curcumin activity. Within the final decade a big number of reports happen to be published on the valuable effects of curcumin (Barchitta et al., 2019) and it has been repeatedly claimed that this organic item is effective and safe for the prevention and treatment of several ailments (Abd El-Hack et al., 2021). In addition, curcumin has been extensively studied for its antioxidant, anti-inflammatory, and wound-healing effects (Menon and Sudheer, 2007; Shirban et al., 2021). This all-natural polyphenol is regarded by some authors as a “wonder drug of life” (Gera et al., 2017) and it really is categorized as a “generally recognized as safe” (GRAS) material, with a stable metabolism and low toxicity (Nelson et al., 2017). More than recent years, food supplements containing Curcuma longa happen to be extensively utilised by an growing variety of shoppers and there is accumulating proof that curcumin might not be so successful and protected. A variety of reports happen to be issued that described the situations of hugely probable drug-induced autoimmune hepatitis (DIAIH) ascribed to ingestion of Curcuma longa dietary supplement (Philips et al., 2020). That is certainly, in contrast with all the use, given that ancient times, of Curcuma longa, as hepatoprotective (Rahmani et al., 2016; Tung et al., 2017; Peng et al., 2018) and for the therapy of digestive tract problems (Gera et al., 2017). Moreover, in literature it truly is reported that curcumin might avoid oxidative stress-related liver disorder causing a series of metabolic reactions as i) decreasing the levels of alanine transaminase (ALT), aspartase transaminase (AST), and alkaline phosphatase (ALP). ii) It increases the expression of glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) whilst further iii) minimizing NO production and inhibiting ROS formation (Farzaei et al., 2018). One of the most widespread substance related with Curcuma longa in its use as meals supplement is piperine from Piper nigrum L. Black pepper (Piper nigrum L.) could be the most utilized specie of pepper and it has identified a worldwide use as a spice. Its history of use in traditional medicine is thousands of years old, being talked about in Ayurvedic medicine treatie