Product Name :
Anti-CD7, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human/Cynomolgus
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-CD7, Human antibody is designed for detecting human CD7 specifically. Anti-CD7, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc. Based on ELISA, Anti-CD7, Human antibody reacts with human CD7, and has reactivity with cynomolgus CD7. | Immunogen: Recombinant human CD7 | Host: Alpaca pacous | Isotype: VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation) | Conjugate: Unconjugated | Specificity: Human CD7 | Cross-Reactivity: Cross-reactivity with cynomolgus CD7 | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C | Background:CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3′-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.Using antibody with Fc(mutation), the background from Fc receptors will be eliminated.
Description2 :
Anti-CD7, Human antibody is designed for detecting human CD7 specifically. Anti-CD7, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc. Based on ELISA, Anti-CD7, Human antibody reacts with human CD7, and has reactivity with cynomolgus CD7.Vunakizumab
Immunogen:
Recombinant human CD7
Host :
Alpaca pacous
Isotype:
VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation)
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc.Giemsa stain The actual dilution used must be determined empirically.PMID:24456950