Product Name :
Anti-CLU, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-CLU, Human antibody is designed for detecting human CLU specifically. Based on ELISA and/or FCM, Anti-CLU, Human antibody reacts with human CLU specifically. | Immunogen: Recombinant human CLU | Host: Alpaca pacous | Isotype: Human IgG1 | Conjugate: Unconjugated | Specificity: Human CLU | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles) | Background:Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB.Naproxen Modulates NF-kappa-B transcriptional activity.Guanabenz (hydrochloride) Nuclear isoforms promote apoptosis.PMID:36717102 Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Description2 :
Anti-CLU, Human antibody is designed for detecting human CLU specifically. Based on ELISA and/or FCM, Anti-CLU, Human antibody reacts with human CLU specifically.
Immunogen:
Recombinant human CLU
Host :
Alpaca pacous
Isotype:
Human IgG1
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles)
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.