Product Name :
Anti-CTLA4, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human/Cynomolgus
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-CTLA4, Human antibody is designed for detecting human CTLA4 specifically. Anti-CTLA4, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc. Based on ELISA, Anti-CTLA4, Human antibody reacts with human CTLA4, and has reactivity with cynomolgus or alpaca CTLA4. | Immunogen: Recombinant human CTLA4 | Host: Alpaca pacous | Isotype: VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation) | Conjugate: Unconjugated | Specificity: Human CTLA4 | Cross-Reactivity: Cross-reactivity with cynomolgus CTLA4 | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C | Background:CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Using antibody with Fc(mutation), the background from Fc receptors will be eliminated.
Description2 :
Anti-CTLA4, Human antibody is designed for detecting human CTLA4 specifically.Diquafosol tetrasodium Anti-CTLA4, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc.Trovafloxacin Based on ELISA, Anti-CTLA4, Human antibody reacts with human CTLA4, and has reactivity with cynomolgus or alpaca CTLA4.PMID:24982871
Immunogen:
Recombinant human CTLA4
Host :
Alpaca pacous
Isotype:
VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation)
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.