Product Name :
DENV-IN-4
Description:
DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect.
CAS:
2762302-75-8
Molecular Weight:
516.66
Formula:
C28H32N4O4Si
Chemical Name:
Smiles :
CC(C)(C)[Si](C)(C)OC1C=CC(=CC=1)[C@H]1N(NC2C=CC(=CC=2)[N+]([O-])=O)C(=O)[C@@H]2CC3=CC=CC=C3N12
InChiKey:
ZDPOOVOOOPKULV-IZZNHLLZSA-N
InChi :
InChI=1S/C28H32N4O4Si/c1-28(2,3)37(4,5)36-23-16-10-19(11-17-23)26-30-24-9-7-6-8-20(24)18-25(30)27(33)31(26)29-21-12-14-22(15-13-21)32(34)35/h6-17,25-26,29H,18H2,1-5H3/t25-,26+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clozapine N-oxide} site|{Clozapine N-oxide} Metabolic Enzyme/Protease|{Clozapine N-oxide} Technical Information|{Clozapine N-oxide} Data Sheet|{Clozapine N-oxide} manufacturer|{Clozapine N-oxide} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Histamine} site|{Histamine} Immunology/Inflammation|{Histamine} Biological Activity|{Histamine} In Vitro|{Histamine} manufacturer|{Histamine} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect.|Product information|CAS Number: 2762302-75-8|Molecular Weight: 516.66|Formula: C28H32N4O4Si|Smiles: CC(C)(C)[Si](C)(C)OC1C=CC(=CC=1)[C@H]1N(NC2C=CC(=CC=2)[N+]([O-])=O)C(=O)[C@@H]2CC3=CC=CC=C3N12|InChiKey: ZDPOOVOOOPKULV-IZZNHLLZSA-N|InChi: InChI=1S/C28H32N4O4Si/c1-28(2,3)37(4,5)36-23-16-10-19(11-17-23)26-30-24-9-7-6-8-20(24)18-25(30)27(33)31(26)29-21-12-14-22(15-13-21)32(34)35/h6-17,25-26,29H,18H2,1-5H3/t25-,26+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24957087 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Qian W, et al. Design, synthesis, discovery and SAR of the fused tricyclic derivatives of indoline and imidazolidinone against DENV replication and infection [published online ahead of print, 2022 Jan 24]. Bioorg Chem. 2022;120:105639.Products are for research use only. Not for human use.|