Product Name :
NLRP3-IN-9
Description:
NLRP3-IN-9 is an inhibitor of caspase-1 and NLRP3 ATPase activities. It acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
CAS:
88039-46-7
Molecular Weight:
240.68
Formula:
C12H13ClO3
Chemical Name:
Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
Smiles :
CCOC(=O)C(=C)C(O)C1=CC=CC=C1Cl
InChiKey:
BSRPDXCMAOIUOO-UHFFFAOYSA-N
InChi :
InChI=1S/C12H13ClO3/c1-3-16-12(15)8(2)11(14)9-6-4-5-7-10(9)13/h4-7,11,14H,2-3H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{LL-37, human} site|{LL-37, human} Anti-infection|{LL-37, human} NF-κB|{LL-37, human} Biological Activity|{LL-37, human} In stock|{LL-37, human} supplier}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NLRP3-IN-9 is an inhibitor of caspase-1 and NLRP3 ATPase activities. It acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.|Product information|CAS Number: 88039-46-7|Molecular Weight: 240.68|Formula: C12H13ClO3|Synonym:|INF4E|Chemical Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate|Smiles: CCOC(=O)C(=C)C(O)C1=CC=CC=C1Cl|InChiKey: BSRPDXCMAOIUOO-UHFFFAOYSA-N|InChi: InChI=1S/C12H13ClO3/c1-3-16-12(15)8(2)11(14)9-6-4-5-7-10(9)13/h4-7,11,14H,2-3H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dehydroepiandrosterone} site|{Dehydroepiandrosterone} Endogenous Metabolite|{Dehydroepiandrosterone} Protocol|{Dehydroepiandrosterone} Purity|{Dehydroepiandrosterone} custom synthesis|{Dehydroepiandrosterone} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:24914310 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Cocco M, Garella D, Di Stilo A, Borretto E, Stevanato L, Giorgis M, Marini E, Fantozzi R, Miglio G, Bertinaria M. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57(24):10366-82. doi: 10.1021/jm501072b. Epub 2014 Dec 4. PubMed PMID: 25418070.Products are for research use only. Not for human use.|