Product Name :
Acrivastine
Description:
Acrivastine (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis.
CAS:
87848-99-5
Molecular Weight:
348.44
Formula:
C22H24N2O2
Chemical Name:
(2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid
Smiles :
CC1=CC=C(C=C1)/C(=C\CN1CCCC1)/C1=CC=CC(/C=C/C(O)=O)=N1
InChiKey:
PWACSDKDOHSSQD-IUTFFREVSA-N
InChi :
InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Adagrasib} MedChemExpress|{Adagrasib} Ras|{Adagrasib} Purity & Documentation|{Adagrasib} Data Sheet|{Adagrasib} manufacturer|{Adagrasib} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Annexin V-FITC/PI Apoptosis Detection Kit} medchemexpress|{Annexin V-FITC/PI Apoptosis Detection Kit} Biological Activity|{Annexin V-FITC/PI Apoptosis Detection Kit} Purity|{Annexin V-FITC/PI Apoptosis Detection Kit} manufacturer|{Annexin V-FITC/PI Apoptosis Detection Kit} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Acrivastine (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis.|Product information|CAS Number: 87848-99-5|Molecular Weight: 348.44|Formula: C22H24N2O2|Chemical Name: (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}prop-2-enoic acid|Smiles: CC1=CC=C(C=C1)/C(=C\CN1CCCC1)/C1=CC=CC(/C=C/C(O)=O)=N1|InChiKey: PWACSDKDOHSSQD-IUTFFREVSA-N|InChi: InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (143.PMID:24982871 50 mM; Need ultrasonic). H2O : 1 mg/mL (2.87 mM; ultrasonic and warming and heat to 80°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Acrivastine (usually 8mg three times daily) is an effective and well tolerated antihistamine in the treatment of chronic urticaria and allergic rhinitis. Acrivastine is more effective than placebo and similar in efficacy to clemastine or terfenadine in the treatment of seasonal allergic rhinitis. In the treatment of dermatoses in which histamine has a pathogenetic role, the efficacy of acrivastine is superior to that of placebo and similar to that of usual dosages of clemastine, hydroxyzine, chlorpheniramine, cyproheptadine or terfenadine. Acrivastine causes less drowsiness than clemastine, the incidence of adverse effects being indistinguishable from that with placebo or terfenadine. Both 4 mg and 8 mg acrivastine alleviate the symptoms of seasonal allergic rhinitis with significant improvements in the symptom scores for sneezing, running nose and the calculated overall score. In addition, 8 mg acrivastine reduces the symptom scores for watery eyes and itchy throat. Acrivastine is both well tolerated and effective in the treatment of seasonal allergic rhinitis.|Products are for research use only. Not for human use.|