Product Name :
CM-579 trihydrochloride
Description:
CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.
CAS:
2448471-08-5
Molecular Weight:
602.04
Formula:
C29H43Cl3N4O3
Chemical Name:
6-methoxy-2-(5-methylfuran-2-yl)-N-[(1-methylpiperidin-4-yl)methyl]-7-[3-(pyrrolidin-1-yl)propoxy]quinolin-4-amine trihydrochloride
Smiles :
Cl.Cl.Cl.CN1CCC(CNC2=CC(=NC3=CC(OCCCN4CCCC4)=C(C=C32)OC)C2=CC=C(C)O2)CC1
InChiKey:
XKSDREMVFCQUPC-UHFFFAOYSA-N
InChi :
InChI=1S/C29H40N4O3.3ClH/c1-21-7-8-27(36-21)26-18-24(30-20-22-9-14-32(2)15-10-22)23-17-28(34-3)29(19-25(23)31-26)35-16-6-13-33-11-4-5-12-33;;;/h7-8,17-19,22H,4-6,9-16,20H2,1-3H3,(H,30,31);3*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Aldosterone} MedChemExpress|{Aldosterone} Endogenous Metabolite|{Aldosterone} Biological Activity|{Aldosterone} Formula|{Aldosterone} supplier|{Aldosterone} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} web|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} IFNAR|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} Immunology/Inflammation|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} Biological Activity|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} References|{Anti-Mouse IFNAR1 Antibody (MAR1-5A3)} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23819239
Additional information:
CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.|Product information|CAS Number: 2448471-08-5|Molecular Weight: 602.04|Formula: C29H43Cl3N4O3|Chemical Name: 6-methoxy-2-(5-methylfuran-2-yl)-N-[(1-methylpiperidin-4-yl)methyl]-7-[3-(pyrrolidin-1-yl)propoxy]quinolin-4-amine trihydrochloride|Smiles: Cl.Cl.Cl.CN1CCC(CNC2=CC(=NC3=CC(OCCCN4CCCC4)=C(C=C32)OC)C2=CC=C(C)O2)CC1|InChiKey: XKSDREMVFCQUPC-UHFFFAOYSA-N|InChi: InChI=1S/C29H40N4O3.3ClH/c1-21-7-8-27(36-21)26-18-24(30-20-22-9-14-32(2)15-10-22)23-17-28(34-3)29(19-25(23)31-26)35-16-6-13-33-11-4-5-12-33;;;/h7-8,17-19,22H,4-6,9-16,20H2,1-3H3,(H,30,31);3*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.33 mg/mL (55.36 mM; Need ultrasonic). H2O : 37.5 mg/mL (62.29 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively.|Products are for research use only. Not for human use.|