Product Name :
6-Iodonordihydrocapsaicin
Description:
IC50: 10 nm against 100 nm capsaicin The vanilloid TRPV1 receptor, also known as VR1 receptor, belongs to the large family of ‘transient receptor potential’ (TRP). TRPV1 functions as a molecular integrator of nociceptive stimuli, including heat, protons and plant toxins, and is most abundant in peripheral sensory fibers of the C and Ad type. 6-iodo-nordihydrocapsaicin is a potent TRPV1 antagonist. In vitro: Using human recombinant TRPV1, 6-Iodonordihydrocapsaicin (IC50=10 nm against 100 nm capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine . In vivo: 6-Iodonordihydrocapsaicin was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. In all cases, except for the guineapig bronchi, the compound was significantly more potent than capsazepine as a TRPV1 antagonist . Clinical trial: Up to now, 6-Iodonordihydrocapsaicin is still in the preclinical development stage.{{Tacrine} medchemexpress|{Tacrine} Neuronal Signaling|{Tacrine} Biological Activity|{Tacrine} Description|{Tacrine} manufacturer|{Tacrine} Autophagy}
CAS:
859171-97-4
Molecular Weight:
419.30
Formula:
C17H26INO3
Chemical Name:
N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide
Smiles :
CCCCCCCCC(=O)NCC1=CC(OC)=C(O)C=C1I
InChiKey:
AAORACFZMYMFCG-UHFFFAOYSA-N
InChi :
InChI=1S/C17H26INO3/c1-3-4-5-6-7-8-9-17(21)19-12-13-10-16(22-2)15(20)11-14(13)18/h10-11,20H,3-9,12H2,1-2H3,(H,19,21)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Toxoflavin} MedChemExpress|{Toxoflavin} Antibiotic|{Toxoflavin} Immunology/Inflammation|{Toxoflavin} Technical Information|{Toxoflavin} Data Sheet|{Toxoflavin} custom synthesis}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IC50: 10 nm against 100 nm capsaicin The vanilloid TRPV1 receptor, also known as VR1 receptor, belongs to the large family of ‘transient receptor potential’ (TRP). TRPV1 functions as a molecular integrator of nociceptive stimuli, including heat, protons and plant toxins, and is most abundant in peripheral sensory fibers of the C and Ad type.PMID:23715856 6-iodo-nordihydrocapsaicin is a potent TRPV1 antagonist. In vitro: Using human recombinant TRPV1, 6-Iodonordihydrocapsaicin (IC50=10 nm against 100 nm capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine . In vivo: 6-Iodonordihydrocapsaicin was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. In all cases, except for the guineapig bronchi, the compound was significantly more potent than capsazepine as a TRPV1 antagonist . Clinical trial: Up to now, 6-Iodonordihydrocapsaicin is still in the preclinical development stage.|Product information|CAS Number: 859171-97-4|Molecular Weight: 419.30|Formula: C17H26INO3|Chemical Name: N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide|Smiles: CCCCCCCCC(=O)NCC1=CC(OC)=C(O)C=C1I|InChiKey: AAORACFZMYMFCG-UHFFFAOYSA-N|InChi: InChI=1S/C17H26INO3/c1-3-4-5-6-7-8-9-17(21)19-12-13-10-16(22-2)15(20)11-14(13)18/h10-11,20H,3-9,12H2,1-2H3,(H,19,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|