Product Name :
Thalidomide-Piperazine-Piperidine
Description:
Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
CAS:
2229716-11-2
Molecular Weight:
425.48
Formula:
C22H27N5O4
Chemical Name:
2-(2, 6-dioxopiperidin-3-yl)-5-[4-(piperidin-4-yl)piperazin-1-yl]-2, 3-dihydro-1H-isoindole-1, 3-dione
Smiles :
O=C1CCC(C(=O)N1)N1C(=O)C2=CC=C(C=C2C1=O)N1CCN(CC1)C1CCNCC1
InChiKey:
LYXHDYJDKVRCIK-UHFFFAOYSA-N
InChi :
InChI=1S/C22H27N5O4/c28-19-4-3-18(20(29)24-19)27-21(30)16-2-1-15(13-17(16)22(27)31)26-11-9-25(10-12-26)14-5-7-23-8-6-14/h1-2,13-14,18,23H,3-12H2,(H,24,28,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.|Product information|CAS Number: 2229716-11-2|Molecular Weight: 425.48|Formula: C22H27N5O4|Chemical Name: 2-(2, 6-dioxopiperidin-3-yl)-5-[4-(piperidin-4-yl)piperazin-1-yl]-2, 3-dihydro-1H-isoindole-1, 3-dione|Smiles: O=C1CCC(C(=O)N1)N1C(=O)C2=CC=C(C=C2C1=O)N1CCN(CC1)C1CCNCC1|InChiKey: LYXHDYJDKVRCIK-UHFFFAOYSA-N|InChi: InChI=1S/C22H27N5O4/c28-19-4-3-18(20(29)24-19)27-21(30)16-2-1-15(13-17(16)22(27)31)26-11-9-25(10-12-26)14-5-7-23-8-6-14/h1-2,13-14,18,23H,3-12H2,(H,24,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{S1p receptor agonist 1} MedChemExpress|{S1p receptor agonist 1} GPCR/G Protein|{S1p receptor agonist 1} Purity & Documentation|{S1p receptor agonist 1} In Vivo|{S1p receptor agonist 1} manufacturer|{S1p receptor agonist 1} Autophagy} |Shelf Life: ≥12 months if stored properly.{{sn-Glycerol 3-phosphate} medchemexpress|{sn-Glycerol 3-phosphate} Metabolic Enzyme/Protease|{sn-Glycerol 3-phosphate} TGF-beta/Smad|{sn-Glycerol 3-phosphate} Protocol|{sn-Glycerol 3-phosphate} Data Sheet|{sn-Glycerol 3-phosphate} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32900248 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.Products are for research use only. Not for human use.|