Product Name :
Mevastatin
Sequence:
Purity:
≥95% (HPLC)
Molecular Weight:
390.5
Solubility :
Soluble in DMSO (20mg/ml) or 100% ethanol (25mg/ml).
Appearance:
White to off-white solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended.
Description:
HMG-CoA reductase inhibitor Mevastatin inhibits isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans.{{937272-79-2} MedChemExpress|{937272-79-2} Technical Information|{937272-79-2} In Vivo|{937272-79-2} manufacturer} It causes cells to arrest early in the G1 phase.{{370-86-5} site|{370-86-5} Technical Information|{370-86-5} In Vitro|{370-86-5} manufacturer} Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities.PMID:30571052 Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.
CAS :
73573-88-3
Solubility:
Soluble in DMSO (20mg/ml) or 100% ethanol (25mg/ml).
Formula:
C23H34O5
Additional Information :
| Alternative Name Compactin | Appearance White to off-white solid. | CAS 73573-88-3 | Couple Target HMG-CoA reductase | Couple Type Inhibitor | Formula C23H34O5 | Identity Determined by 1H-NMR. | MW 390.5 | Purity ≥95% (HPLC) | Solubility Soluble in DMSO (20mg/ml) or 100% ethanol (25mg/ml). | Unit of Measure (UM) mg