Product Name :
AZD7594
Description:
AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM.
CAS:
1196509-60-0
Molecular Weight:
606.62
Formula:
C32H32F2N4O6
Chemical Name:
3-5-[(1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]-1H-indazol-1-yl-N-[(3R)-oxolan-3-yl]benzamide
Smiles :
C[C@H](NC(=O)C(C)(F)F)[C@H](OC1C=CC2=C(C=NN2C2C=CC=C(C=2)C(=O)N[C@H]2COCC2)C=1)C1=CC=C2OCCOC2=C1
InChiKey:
ZZWJKLGCDHYVMB-BWGXUDETSA-N
InChi :
InChI=1S/C32H32F2N4O6/c1-19(36-31(40)32(2,33)34)29(20-6-9-27-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9,14-17,19,23,29H,10-13,18H2,1-2H3,(H,36,40)(H,37,39)/t19-,23+,29-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM.|Product information|CAS Number: 1196509-60-0|Molecular Weight: 606.62|Formula: C32H32F2N4O6|Chemical Name: 3-5-[(1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]-1H-indazol-1-yl-N-[(3R)-oxolan-3-yl]benzamide|Smiles: C[C@H](NC(=O)C(C)(F)F)[C@H](OC1C=CC2=C(C=NN2C2C=CC=C(C=2)C(=O)N[C@H]2COCC2)C=1)C1=CC=C2OCCOC2=C1|InChiKey: ZZWJKLGCDHYVMB-BWGXUDETSA-N|InChi: InChI=1S/C32H32F2N4O6/c1-19(36-31(40)32(2,33)34)29(20-6-9-27-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9,14-17,19,23,29H,10-13,18H2,1-2H3,(H,36,40)(H,37,39)/t19-,23+,29-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 83.Complement factor H/CFH Protein, Human (431a.a, HEK293, C-His) manufacturer 3 mg/mL (137.Bromothymol Blue Purity & Documentation 32 mM).PMID:33230550 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM).|In Vivo:|AZD7594 has anti-inflammatory activity, and efficiently inhibits rat lung edema.|Products are for research use only. Not for human use.|