Product Name :
Rabbit anti-Ubiquitin Monoclonal Antibody
Synonym :
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
Predicted Reactivity:
Applications :
WB:1: 500-1: 2000; ICC/IF:1: 50
Immunogen:
Concentration :
Purification :
Protein A
Clonality:
Monoclonal Antibody
Storage Temp.:
Storage temperature: -20 ℃, avoid repeated freezing and thawing
Research areas :
Background :
Ubiquitin is an 8-kda protein with a highly conserved sequence that is covalently linked to lysine residues in the target protein. The ubiquitination process involves three regulatory steps, which are mediated by ubiquitin activating enzyme (E1), ubiquitin coupling enzyme (E2) and ubiquitin ligase enzyme (E3). The ubiquitination process is usually regulated by the formation of polyubiquitin chains, Polyubiquitination refers to the binding of the carboxyl terminus of one ubiquitin protein to the N terminus of another ubiquitin protein or to the seven Lysines in the ubiquitin protein (Lys-6, Lys-11, Lys-27,Lys-29, Lys-33, Lys-48, Lys-33, Lys-48, and Lys-27). and Lys-63). Lysine ubiquitination plays a central role in the regulation of multiple cellular processes. In addition to tagging targeted proteins for proteasomal degradation, ubiquitination regulates membrane protein trafficking, alters protein-protein interactions, and regulates the activity of multiple signal transduction pathways. Ubiquitin binding involves a large family of enzymes and regulates a variety of functions.
UniProt :
P62979
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Host Rabbit |Species Reactivity Human, Mouse, Rat |Applications WB:1: 500-1: 2000; ICC/IF:1: 50 |Properties |Form Liquid |Purification Protein A |Clonality Monoclonal Antibody |Isotype IgG |Storage Temp. Storage temperature: -20 ℃, avoid repeated freezing and thawing |Target |Background Ubiquitin is an 8-kda protein with a highly conserved sequence that is covalently linked to lysine residues in the target protein. The ubiquitination process involves three regulatory steps, which are mediated by ubiquitin activating enzyme (E1), ubiquitin coupling enzyme (E2) and ubiquitin ligase enzyme (E3). The ubiquitination process is usually regulated by the formation of polyubiquitin chains, Polyubiquitination refers to the binding of the carboxyl terminus of one ubiquitin protein to the N terminus of another ubiquitin protein or to the seven Lysines in the ubiquitin protein (Lys-6, Lys-11, Lys-27,Lys-29, Lys-33, Lys-48, Lys-33, Lys-48, and Lys-27). and Lys-63). Lysine ubiquitination plays a central role in the regulation of multiple cellular processes. In addition to tagging targeted proteins for proteasomal degradation, ubiquitination regulates membrane protein trafficking, alters protein-protein interactions, and regulates the activity of multiple signal transduction pathways. Ubiquitin binding involves a large family of enzymes and regulates a variety of functions. |Cellular localization Cell nucleus |UniProt P62979 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-Ubiquitin Monoclonal Antibody
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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