N-Acetyl-L-alanine
N-Acetyl-L-alanine is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Myelin basic protein, GTP-binding nuclear protein Ran, Tropomyosin alpha 4 chain, HIV-1 Rev binding protein 2, Xaa-Pro dipeptidase, Thymosin beta-10, Actin-like protein 3, Alanine aminotransferase, Serine/threonine protein phosphatase PP1-beta catalytic subunit, 10 kDa heat shock protein (mitochondrial), Calmodliin and Beta-1-syntrophin.
Structure for HMDB00766 (N-Acetyl-L-alanine)
C5H9NO3
131.1299
131.058243159
(2S)-2-acetamidopropanoic acid
N-acetylalanine
97-69-8
KTHDTJVBEPMMGL-VKHMYHEASA-N
This compound belongs to the class of chemical entities known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom.
Chemical entities
Organic compounds
Organic acids and derivatives
Carboxylic acids and derivatives
N-acyl-L-alpha-amino acids
Aliphatic acyclic compounds
Detected and Quantified
Not Available
Solid
GC-MS Spectrum – GC-MS (1 TMS)splash10-05n0-2900000000-c0a5e66723f41ac78751View in MoNA
Predicted GC-MS Spectrum – GC-MSNot Available
LC-MS/MS Spectrum – Quattro_QQQ 10V, Positive (Annotated)splash10-0006-9000000000-4cea4517104b7a324debView in MoNA
LC-MS/MS Spectrum – Quattro_QQQ 25V, Positive (Annotated)splash10-0006-9000000000-4497242e6b422cf3f913View in MoNA
LC-MS/MS Spectrum – Quattro_QQQ 40V, Positive (Annotated)splash10-0006-9000000000-22d764f7b773b82c6515View in MoNA
LC-MS/MS Spectrum – LC-ESI-ITFT , negativesplash10-000i-9000000000-e6becb5f8b8bbb53304aView in MoNA
Predicted LC-MS/MS Spectrum – 10V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 20V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 40V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 10V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 20V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 40V, NegativeNot Available
13C NMR SpectrumNot Available
1H NMR SpectrumNot Available
[1H,1H] 2D NMR SpectrumNot Available
[1H,13C] 2D NMR SpectrumNot Available
Not Available
Not Available
Prostate Cancer
- Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
Not Available
Not Available
Not Available
Not Available
FDB022231
Not Available
79449
Not Available
Not Available
Not Available
Not Available
HMDB00766
HMDB00766
5733
88064
AYA
40992
Enzymes
- General function:
- Involved in catalytic activity
- Specific function:
- Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
- Gene Name:
- CPS1
- Uniprot ID:
- P31327
- Molecular weight:
- 165649.075
- General function:
- Involved in N-acetyltransferase activity
- Specific function:
- Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.
- Gene Name:
- NAGS
- Uniprot ID:
- Q8N159
- Molecular weight:
- 58155.835
- General function:
- Involved in glycine N-acyltransferase activity
- Specific function:
- Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
- Gene Name:
- GLYAT
- Uniprot ID:
- Q6IB77
- Molecular weight:
- 18506.33
- General function:
- Involved in glycine N-acyltransferase activity
- Specific function:
- Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.
- Gene Name:
- GLYATL1
- Uniprot ID:
- Q969I3
- Molecular weight:
- 35100.895
- General function:
- Involved in glycine N-acyltransferase activity
- Specific function:
- Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.
- Gene Name:
- GLYATL2
- Uniprot ID:
- Q8WU03
- Molecular weight:
- 34277.055