Re depicted in Figure 3A and 3B, respectively. There were no statistically 
significant differences in death between groups.Low versus high balloon inflation pressure Results Patient and procedure characteristicsDuring the study period 94 342 stents were used, 645 were excluded due to incomplete data, I-BRD9 site leaving 93 697 stents eligible for analysis. We divided the material into five different groups representing a compromise between the number of stents per group and clinical relevance: #15 atm, 
16?7 atm, 18?9 atm, 20?1 atm and 22 atm. In Tables 1 and 2 baseline and procedural variables are 25033180 listed. Many variables were numerically almost identical. However, more men and AKT inhibitor 2 higher proportions of risk factors such as diabetes mellitus, hypertension and hyperlipidemia were found in the high pressure groups (Table 1). Moreover, bivalirudin was very often used in association with stents in the #15 atm pressure group while heparins were more often used in the high pressure groups (Table 2). Also the use of drug-eluting stents and post-dilatation were more prevalent in the high pressure groups. Follow-up time was approximately 2 years for all groups (Table 2). Clinically and considering the imprecision of balloon inflation device manometers it could be reasoned that a division into “low” and “high” balloon inflation pressures would make the findings easier to interpret from an individual patient’s point of view. We defined a low balloon inflation pressure as #18 atm (50 665 stents) and a high pressure as 19 atm (43 032 stents). The RR risk for stent thrombosis demonstrated a statistically non-significant trend towards increased risk with a low balloon pressure (RR 1.14 (CI: 0.98?.32) P = 0.084). For restenosis (RR 1.05 (CI: 0.98?.12) P = 0.16) and mortality (RR: 0.94 (CI 0.85?.05) P = 0.27) no differences were found.Post-dilatationOverall, post-dilation was not associated with a statistically significant lower risk of stent thrombosis (Figure 4A). Restenosis was more often seen following post-dilatation and this reached statistical significance (Figure 4B). For both variables the KaplanMeier curves separated after approximately one year. Conversely, mortality was higher in patients where post-dilatation was not performed and the curves separated shortly after PCI (Figure 4C). Because the most optimal stent inflation pressure with respect to stent thrombosis and restenosis appeared to be 20?1 atm we did a separate analysis of the effect of post-dilatation within this pressure interval which is routinely used both 24786787 as the highest inflation pressure during stenting with and without post-dilatation. In this analysis the use of post-dilatation was associated with a RR of stent thrombosis at one year of 1.56 (CI: (1.10?.23) P = 0.013), the RR of restenosis was 1.15 (CI: (0.98?.34) P = 0.079) and the RR of death was 0.89 (CI: (0.71?.12) P = 0.330).Stent thrombosisDuring the study period 999 stent thromboses were reported. The one-year incidence and the cumulative incidence of stent thrombosis in relation to stent inflation pressure are depicted in Figure 1A and 1B, respectively. With the 20?1 atm group as reference the risk of stent thrombosis was significantly higher in the #15 atm, 18?9 atm and 22 atm groups (Figure 1B). In order to rule out possible bias related to a “per stent” analysis we repeated the analysis for patients stented for the first time and only receiving a single stent. In this group of 27 893 patients 284 stent thromboses were repo.Re depicted in Figure 3A and 3B, respectively. There were no statistically significant differences in death between groups.Low versus high balloon inflation pressure Results Patient and procedure characteristicsDuring the study period 94 342 stents were used, 645 were excluded due to incomplete data, leaving 93 697 stents eligible for analysis. We divided the material into five different groups representing a compromise between the number of stents per group and clinical relevance: #15 atm, 16?7 atm, 18?9 atm, 20?1 atm and 22 atm. In Tables 1 and 2 baseline and procedural variables are 25033180 listed. Many variables were numerically almost identical. However, more men and higher proportions of risk factors such as diabetes mellitus, hypertension and hyperlipidemia were found in the high pressure groups (Table 1). Moreover, bivalirudin was very often used in association with stents in the #15 atm pressure group while heparins were more often used in the high pressure groups (Table 2). Also the use of drug-eluting stents and post-dilatation were more prevalent in the high pressure groups. Follow-up time was approximately 2 years for all groups (Table 2). Clinically and considering the imprecision of balloon inflation device manometers it could be reasoned that a division into “low” and “high” balloon inflation pressures would make the findings easier to interpret from an individual patient’s point of view. We defined a low balloon inflation pressure as #18 atm (50 665 stents) and a high pressure as 19 atm (43 032 stents). The RR risk for stent thrombosis demonstrated a statistically non-significant trend towards increased risk with a low balloon pressure (RR 1.14 (CI: 0.98?.32) P = 0.084). For restenosis (RR 1.05 (CI: 0.98?.12) P = 0.16) and mortality (RR: 0.94 (CI 0.85?.05) P = 0.27) no differences were found.Post-dilatationOverall, post-dilation was not associated with a statistically significant lower risk of stent thrombosis (Figure 4A). Restenosis was more often seen following post-dilatation and this reached statistical significance (Figure 4B). For both variables the KaplanMeier curves separated after approximately one year. Conversely, mortality was higher in patients where post-dilatation was not performed and the curves separated shortly after PCI (Figure 4C). Because the most optimal stent inflation pressure with respect to stent thrombosis and restenosis appeared to be 20?1 atm we did a separate analysis of the effect of post-dilatation within this pressure interval which is routinely used both 24786787 as the highest inflation pressure during stenting with and without post-dilatation. In this analysis the use of post-dilatation was associated with a RR of stent thrombosis at one year of 1.56 (CI: (1.10?.23) P = 0.013), the RR of restenosis was 1.15 (CI: (0.98?.34) P = 0.079) and the RR of death was 0.89 (CI: (0.71?.12) P = 0.330).Stent thrombosisDuring the study period 999 stent thromboses were reported. The one-year incidence and the cumulative incidence of stent thrombosis in relation to stent inflation pressure are depicted in Figure 1A and 1B, respectively. With the 20?1 atm group as reference the risk of stent thrombosis was significantly higher in the #15 atm, 18?9 atm and 22 atm groups (Figure 1B). In order to rule out possible bias related to a “per stent” analysis we repeated the analysis for patients stented for the first time and only receiving a single stent. In this group of 27 893 patients 284 stent thromboses were repo.