Estrict flexible operation. We investigate a segmented tray column developed to let flexible operation. The style consists of radial trays connected in the downcomer of every tray. Every single segment could be operated separately, but based on the capacity with the feed stream, more segments is often activated or deactivated. The connection between the trays aims to transfer liquid from one sn-Glycerol 3-phosphate Autophagy particular stationary segment to the adjacent inactive segment, thereby minimizing the time required for the start-up procedure. In a case study on the separation of methanol and water, we execute dynamic simulations to assess the reduction in the start-up time of inactive segments. The results confirm the advantages over typical tray styles. The segmented distillation column is really a step towards improving the flexibility of separation operations. Keyword phrases: distillation; start-up; flexibility; dynamic simulation; column designCitation: Bruns, B.; Fasel, H.; Gr ewald, M.; Riese, J. Development of a Dynamic Modeling Method to Simulate a Segmented Distillation Column for Versatile Operation. ChemEngineering 2021, 5, 66. https://doi.org/10.3390/ chemengineering5040066 Academic Editor: Andrew S. Paluch Received: 9 August 2021 Accepted: 29 September 2021 Published: 1 October1. Introduction The chemical industry is confronted with many challenges which include an uncertain provide of raw components, globalization of markets and volatile power markets. Options for these challenges are at the moment investigated in numerous regions of chemical engineering. This involves, e.g., new developments in process systems engineering [1] and course of action synthesis [2], but in addition in approaches for instance procedure intensification [3,4] and demand-sidemanagement [5]. In the majority of these locations, improving the flexibility of chemical systems is seen as a essential element to deal with the increasing uncertainties. There has been important research on how you can quantify and boost flexibility for chemical systems primarily based around the perform of Grossmann and his coworkers for steady-state Cefalonium Anti-infection operation [6,7], which was also extended for dynamic operation [8]. The developed mathematical strategies are strong tools to adapt and retrofit chemical processes in terms of their flexibility [9]. These approaches may be employed to optimize approach parameters so that you can improve flexibility. Besides these solutions, new technical approaches are getting developed to allow to get a much more flexible operation of method systems. The solutions encompass approaches for scheduling and handle, and the advancement of existing unit operations. Study for scheduling and manage is broadly available [105], whereas advancements in unit operations are scarce. Some examples is often discovered in reaction engineering [16,17]. This can be also particularly applicable for separation technologies including distillation columns. The flexibility of a distillation column with regards to its feed mass flow largely will depend on the kind of internals. If the feed capacity from the column changes considerably, various hydrodynamic phenomena occur that limit the feasible area of the column. When perturbation of those limits appear, solutions might turn out to be off-spec or the operation fails totally. Flexible operation, for that reason, requires a column design and style that will operatePublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access write-up distri.